Blockade of adrenaline-induced hyperglycemia in the anesthetized cat by continuous infusion of phentolamine and propranolol

L. M. Al-Jibouri, B. L. Furman, J. Parratt

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of adrenoceptor blocking drugs on the metabolic responses to adrenaline infusion (1 μg kg-1 min-1) have been studied in the anesthetized, fasted cat. Propranolol, in doses (0.25 or 1 mg/kg) which prevented completely adrenaline-induced tachycardia, reduced but did not abolish adrenaline-induced hyperglycemia. Phentolamine infusion, at a rate (15 μg kg-1 min-1 after a priming dose of 2.5 mg/kg) which reversed the pressor effect of adrenaline, reduced but did not abolish adrenaline-induced hyperglycemia. The continuous infusion of a combination of phentolamine (15 μg kg-1 min-1 after a priming dose of 2.5 mg/kg) and propranolol (5 μg kg-1 min-1 after a priming dose of 0.25 mg/kg) prevented completely the hyperglycemia response to adrenaline infusion over a 6 hr period. The increase in blood lactate concentration produced by adrenaline was prevented completely by the combined infusion of propranolol and phentolamine but was not modified by phentolamine alone.

Original languageEnglish
Pages (from-to)461-466
Number of pages6
JournalBritish Journal of Pharmacology
Volume68
Issue number3
Publication statusPublished - 1980

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Phentolamine
Propranolol
Hyperglycemia
Epinephrine
Cats
Tachycardia
Adrenergic Receptors
Lactic Acid
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Blockade of adrenaline-induced hyperglycemia in the anesthetized cat by continuous infusion of phentolamine and propranolol. / Al-Jibouri, L. M.; Furman, B. L.; Parratt, J.

In: British Journal of Pharmacology, Vol. 68, No. 3, 1980, p. 461-466.

Research output: Contribution to journalArticle

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