Blind spot for sedentarism

Redefining the diseasome of physical inactivity in view of circadian system and the Irisin/BDNF axis

Judit Zsuga, Csaba E. More, Tamas Erdei, C. Papp, Szilvia Harsanyi, R. Gesztelyi

Research output: Contribution to journalArticle

Abstract

Introduction: The term "diseasome of physical inactivity" was coined by Pedersen to explain clustering of chronic diseases linked to physical inactivity. Accordingly, physical inactivity per se contributes to the accumulation of visceral fat, which, generates chronic low-grade systemic inflammation, contributes to emergence of chronic, noncommunicable diseases. Diversity of these disorders posits the possible involvement of a supraphysiological system. Methods: Hypothesis driven literature search and deductive reasoning was used to review relevant literature and formulate a novel theory. Results: We have identified the circadian system, omnipresent in virtually every cell, as a possible vehicle for brain muscle crosstalk, explaining some aspects of the diseasome of physical inactivity This system is hierarchically organized, with the suprachiasmatic nucleus (SCN) being the master clock that entrains to the dark/light cycle and synchronizes subsidiary molecular clocks in the periphery. Insufficient photic entrainment also causes chronic disease evolution. The recently identified irisin, was shown to induce brain-derived neurotrophic factor (BDNF) production in several brain areas. BDNF assumes significant role in gating light's influence in the retinohypothalamic synapse, by having a permissive effect on glutamate signal transduction underlying photic entrainment. Conclusions: Here we provide theoretical evidence to support the hypothesis that irisin may facilitate photic entrainment of the SCN, via BDNF. By this irisin opens up possible pathways for peripheral nonphotic entrainment signals to exert influence on the master clock that is otherwise resistant to these. Furthermore, we suggest that intertwining processes of circadian, redox, inflammatory, and myokine systems lay underneath the diseasome of physical inactivity.

Original languageEnglish
Article number818
JournalFrontiers in Neurology
Volume9
Issue numberOCT
DOIs
Publication statusPublished - Oct 1 2018

Fingerprint

Brain-Derived Neurotrophic Factor
Optic Disk
Suprachiasmatic Nucleus
Chronic Disease
Intra-Abdominal Fat
Photoperiod
Brain
Synapses
Oxidation-Reduction
Cluster Analysis
Glutamic Acid
Signal Transduction
Inflammation
Muscles

Keywords

  • BDNF
  • Circadian rhythm
  • Entrainment
  • Irisin
  • Physical inactivity
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Blind spot for sedentarism : Redefining the diseasome of physical inactivity in view of circadian system and the Irisin/BDNF axis. / Zsuga, Judit; More, Csaba E.; Erdei, Tamas; Papp, C.; Harsanyi, Szilvia; Gesztelyi, R.

In: Frontiers in Neurology, Vol. 9, No. OCT, 818, 01.10.2018.

Research output: Contribution to journalArticle

@article{7a2768ba4cf84a23bf1ab8f8f0f58e9f,
title = "Blind spot for sedentarism: Redefining the diseasome of physical inactivity in view of circadian system and the Irisin/BDNF axis",
abstract = "Introduction: The term {"}diseasome of physical inactivity{"} was coined by Pedersen to explain clustering of chronic diseases linked to physical inactivity. Accordingly, physical inactivity per se contributes to the accumulation of visceral fat, which, generates chronic low-grade systemic inflammation, contributes to emergence of chronic, noncommunicable diseases. Diversity of these disorders posits the possible involvement of a supraphysiological system. Methods: Hypothesis driven literature search and deductive reasoning was used to review relevant literature and formulate a novel theory. Results: We have identified the circadian system, omnipresent in virtually every cell, as a possible vehicle for brain muscle crosstalk, explaining some aspects of the diseasome of physical inactivity This system is hierarchically organized, with the suprachiasmatic nucleus (SCN) being the master clock that entrains to the dark/light cycle and synchronizes subsidiary molecular clocks in the periphery. Insufficient photic entrainment also causes chronic disease evolution. The recently identified irisin, was shown to induce brain-derived neurotrophic factor (BDNF) production in several brain areas. BDNF assumes significant role in gating light's influence in the retinohypothalamic synapse, by having a permissive effect on glutamate signal transduction underlying photic entrainment. Conclusions: Here we provide theoretical evidence to support the hypothesis that irisin may facilitate photic entrainment of the SCN, via BDNF. By this irisin opens up possible pathways for peripheral nonphotic entrainment signals to exert influence on the master clock that is otherwise resistant to these. Furthermore, we suggest that intertwining processes of circadian, redox, inflammatory, and myokine systems lay underneath the diseasome of physical inactivity.",
keywords = "BDNF, Circadian rhythm, Entrainment, Irisin, Physical inactivity, Suprachiasmatic nucleus",
author = "Judit Zsuga and More, {Csaba E.} and Tamas Erdei and C. Papp and Szilvia Harsanyi and R. Gesztelyi",
year = "2018",
month = "10",
day = "1",
doi = "10.3389/fneur.2018.00818",
language = "English",
volume = "9",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",
number = "OCT",

}

TY - JOUR

T1 - Blind spot for sedentarism

T2 - Redefining the diseasome of physical inactivity in view of circadian system and the Irisin/BDNF axis

AU - Zsuga, Judit

AU - More, Csaba E.

AU - Erdei, Tamas

AU - Papp, C.

AU - Harsanyi, Szilvia

AU - Gesztelyi, R.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Introduction: The term "diseasome of physical inactivity" was coined by Pedersen to explain clustering of chronic diseases linked to physical inactivity. Accordingly, physical inactivity per se contributes to the accumulation of visceral fat, which, generates chronic low-grade systemic inflammation, contributes to emergence of chronic, noncommunicable diseases. Diversity of these disorders posits the possible involvement of a supraphysiological system. Methods: Hypothesis driven literature search and deductive reasoning was used to review relevant literature and formulate a novel theory. Results: We have identified the circadian system, omnipresent in virtually every cell, as a possible vehicle for brain muscle crosstalk, explaining some aspects of the diseasome of physical inactivity This system is hierarchically organized, with the suprachiasmatic nucleus (SCN) being the master clock that entrains to the dark/light cycle and synchronizes subsidiary molecular clocks in the periphery. Insufficient photic entrainment also causes chronic disease evolution. The recently identified irisin, was shown to induce brain-derived neurotrophic factor (BDNF) production in several brain areas. BDNF assumes significant role in gating light's influence in the retinohypothalamic synapse, by having a permissive effect on glutamate signal transduction underlying photic entrainment. Conclusions: Here we provide theoretical evidence to support the hypothesis that irisin may facilitate photic entrainment of the SCN, via BDNF. By this irisin opens up possible pathways for peripheral nonphotic entrainment signals to exert influence on the master clock that is otherwise resistant to these. Furthermore, we suggest that intertwining processes of circadian, redox, inflammatory, and myokine systems lay underneath the diseasome of physical inactivity.

AB - Introduction: The term "diseasome of physical inactivity" was coined by Pedersen to explain clustering of chronic diseases linked to physical inactivity. Accordingly, physical inactivity per se contributes to the accumulation of visceral fat, which, generates chronic low-grade systemic inflammation, contributes to emergence of chronic, noncommunicable diseases. Diversity of these disorders posits the possible involvement of a supraphysiological system. Methods: Hypothesis driven literature search and deductive reasoning was used to review relevant literature and formulate a novel theory. Results: We have identified the circadian system, omnipresent in virtually every cell, as a possible vehicle for brain muscle crosstalk, explaining some aspects of the diseasome of physical inactivity This system is hierarchically organized, with the suprachiasmatic nucleus (SCN) being the master clock that entrains to the dark/light cycle and synchronizes subsidiary molecular clocks in the periphery. Insufficient photic entrainment also causes chronic disease evolution. The recently identified irisin, was shown to induce brain-derived neurotrophic factor (BDNF) production in several brain areas. BDNF assumes significant role in gating light's influence in the retinohypothalamic synapse, by having a permissive effect on glutamate signal transduction underlying photic entrainment. Conclusions: Here we provide theoretical evidence to support the hypothesis that irisin may facilitate photic entrainment of the SCN, via BDNF. By this irisin opens up possible pathways for peripheral nonphotic entrainment signals to exert influence on the master clock that is otherwise resistant to these. Furthermore, we suggest that intertwining processes of circadian, redox, inflammatory, and myokine systems lay underneath the diseasome of physical inactivity.

KW - BDNF

KW - Circadian rhythm

KW - Entrainment

KW - Irisin

KW - Physical inactivity

KW - Suprachiasmatic nucleus

UR - http://www.scopus.com/inward/record.url?scp=85055084738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055084738&partnerID=8YFLogxK

U2 - 10.3389/fneur.2018.00818

DO - 10.3389/fneur.2018.00818

M3 - Article

VL - 9

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

IS - OCT

M1 - 818

ER -