Blastic transformation of mantle cell lymphoma: Genetic evidence for a clonal link between the two stages of the tumour

T. László, A. Matolcsy

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aims: The blastic variant of mantle cell lymphoma (MCL-BV) may develop through histological transformation of mantle cell lymphoma (MCL). However, the clonal link between the tumour cells of MCL and transformed MCL-BV has not been established at the genetic level. To investigate this link longitudinal molecular genetic studies have been performed in two cases of MCL that showed morphological transformation to MCL-BV. Methods and results: Polymerase chain reaction (PCR) and nucleotide sequence analyses of the complementary determining region 3 (CDR) of the immunoglobulin (Ig) heavy chain (H) gene were performed to identify clone-specific rearrangements. In both cases, nucleotide sequence analysis revealed common clone-specific IgH gene rearrangements in MCL and subsequent MCL-BV. Conclusions: These results provide genetic evidence for the common clonal origin of MCL and subsequently developed MCL-BV.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
JournalHistopathology
Volume35
Issue number4
DOIs
Publication statusPublished - 1999

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Mantle-Cell Lymphoma
Neoplasms
Sequence Analysis
Clone Cells
Immunoglobulin Heavy Chain Genes
Gene Rearrangement
Molecular Biology

Keywords

  • Blastic transformation
  • Clonality
  • Mantle cell lymphoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Blastic transformation of mantle cell lymphoma : Genetic evidence for a clonal link between the two stages of the tumour. / László, T.; Matolcsy, A.

In: Histopathology, Vol. 35, No. 4, 1999, p. 355-359.

Research output: Contribution to journalArticle

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