Bismuth(III)-Catalyzed hydration of terminal alkynes: Sustainable synthesis of methyl ketones in batch and flow

Sándor B. Ötvös, Zsanett Szécsényi, Ferenc Fülöp

Research output: Contribution to journalArticle

Abstract

Environmentally benign synthesis of methyl ketones is demonstrated via unprecedented bismuth(III)-catalyzed activation and Markovnikov-type hydration of terminal acetylenes. Besides a batch process operating under reasonably mild conditions, a chemically intensified high-temperature continuous-flow methodology has also been developed using a coil reactor. The preparative capabilities of the flow process were demonstrated with multigram-scale alkyne hydrations. The methods presented rely on readily available bismuth(III) salts as "green" catalysts and exhibit less environmental concerns than earlier methods.

Original languageEnglish
Pages (from-to)13286-13293
Number of pages8
JournalACS Sustainable Chemistry and Engineering
Volume7
Issue number15
DOIs
Publication statusPublished - Aug 5 2019

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Keywords

  • Alkynes
  • Bismuth
  • Flow chemistry
  • Hydration
  • Ketones

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Renewable Energy, Sustainability and the Environment

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