Bis(3-hydroxy-4-pyridinone)-EDTA derivative as a potential therapeutic Al-chelating agent. Synthesis, solution studies and biological assays

M. Amélia Santos, Sofia Gama, Lurdes Gano, Etelka Farkas

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The 3-hydroxy-4-pyridinones are chelating agents of current interest due to their high affinity for hard metal ions and potential clinical applications as metal-decorporation agents. A new bis-(3-hydroxy-4-pyridinone) derivative of EDTA have been developed, and herein we describe the results of solution studies to determine the protonation constants and the partition coefficient. Biodistribution studies, performed with 67Ga-overload mice, showed rapid clearance of the radiotracer from the body, thus indicating that the new ligand should be a quite effective agent for the in vivo aluminium removal.

Original languageEnglish
Pages (from-to)1845-1852
Number of pages8
JournalJournal of Inorganic Biochemistry
Volume99
Issue number9 SPEC. ISS.
DOIs
Publication statusPublished - Sep 2005

Keywords

  • 3-hydroxy-4-pyridinones
  • Al-chelator
  • Chelating agent
  • Hydroxypyridinonate complexes

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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