Biphasic effects of a potent enkephalin analogue (d-Met2,Pro5)-enkephalinamide and morphine on locomotor activity in mice

J. I Székely E Miglécz, A. Rónai

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of morphine and a potent enkephalin analogue on spontaneous locomotion have been compared in mice. In doses of 3-10 mg/kg SC both compounds induced a brief reduction of motor activity followed by a period of behavioral hyperactivity. Similar receptorial mechanisms are suggested in mediation of their motor effects.

Original languageEnglish
Pages (from-to)299-301
Number of pages3
JournalPsychopharmacology
Volume71
Issue number3
DOIs
Publication statusPublished - Dec 1980

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Enkephalins
Locomotion
Morphine
Motor Activity

Keywords

  • (d-Met,Pro)-enkephalinamide
  • Morphine
  • Opioid peptides
  • Spontaneous locomotor activity

ASJC Scopus subject areas

  • Pharmacology

Cite this

Biphasic effects of a potent enkephalin analogue (d-Met2,Pro5)-enkephalinamide and morphine on locomotor activity in mice. / Miglécz, J. I Székely E; Rónai, A.

In: Psychopharmacology, Vol. 71, No. 3, 12.1980, p. 299-301.

Research output: Contribution to journalArticle

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