Biotransformation of BMOV in the presence of blood serum proteins

Daniele Sanna, Linda Bíró, Péter Buglyó, Giovanni Micera, Eugenio Garribba

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The interaction of the potent anti-diabetic agent bis(maltolato) oxidovanadium(iv) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma) 2(hTf), cis-VO(ma) 2(HSA) and cis-VO(ma) 2(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalMetallomics
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 1 2012

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ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Biophysics
  • Biomaterials
  • Biochemistry
  • Metals and Alloys

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