Biotransformation of BMOV in the presence of blood serum proteins

Daniele Sanna, Linda Bíró, P. Buglyó, Giovanni Micera, Eugenio Garribba

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The interaction of the potent anti-diabetic agent bis(maltolato) oxidovanadium(iv) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma) 2(hTf), cis-VO(ma) 2(HSA) and cis-VO(ma) 2(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalMetallomics
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Potentiometry
Biotransformation
Discrete Fourier transforms
Paramagnetic resonance
Blood Proteins
Spectrum Analysis
Blood
Immunoglobulin G
Spectroscopy
Proteins
Serum

ASJC Scopus subject areas

  • Biomaterials
  • Metals and Alloys
  • Chemistry (miscellaneous)
  • Biochemistry
  • Biophysics

Cite this

Biotransformation of BMOV in the presence of blood serum proteins. / Sanna, Daniele; Bíró, Linda; Buglyó, P.; Micera, Giovanni; Garribba, Eugenio.

In: Metallomics, Vol. 4, No. 1, 01.2012, p. 33-36.

Research output: Contribution to journalArticle

Sanna, D, Bíró, L, Buglyó, P, Micera, G & Garribba, E 2012, 'Biotransformation of BMOV in the presence of blood serum proteins', Metallomics, vol. 4, no. 1, pp. 33-36. https://doi.org/10.1039/c1mt00161b
Sanna, Daniele ; Bíró, Linda ; Buglyó, P. ; Micera, Giovanni ; Garribba, Eugenio. / Biotransformation of BMOV in the presence of blood serum proteins. In: Metallomics. 2012 ; Vol. 4, No. 1. pp. 33-36.
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