Biophysical characteristics of proteins and living cells exposed to the green tea polyphenol epigallocatechin-3-gallate (EGCg): review of recent advances from molecular mechanisms to nanomedicine and clinical trials

Beatrix Peter, Sz. Bősze, R. Horváth

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Herbs and traditional medicines have been applied for thousands of years, but researchers started to study their mode of action at the molecular, cellular and tissue levels only recently. Nowadays, just like in ancient times, natural compounds are still determining factors in remedies. To support this statement, the recently won Nobel Prize for an anti-malaria agent from the plant sweet wormwood, which had been used to effectively treat the disease, could be mentioned. Among natural compounds and traditional Chinese medicines, the green tea polyphenol epigallocatechin gallate (EGCg) is one of the most studied active substances. In the present review, we summarize the molecular scale interactions of proteins and EGCg with special focus on its limited stability and antioxidant properties. We outline the observed biophysical effects of EGCg on various cell lines and cultures. The alteration of cell adhesion, motility, migration, stiffness, apoptosis, proliferation as well as the different impacts on normal and cancer cells are all reviewed. We also handle the works performed using animal models, microbes and clinical trials. Novel ways to develop its utilization for therapeutic purposes in the future are discussed too, for instance, using nanoparticles and green tea polyphenols together to cure illnesses and the combination of EGCg and anticancer compounds to intensify their effects. The limitations of the employed experimental models and criticisms of the interpretation of the obtained experimental data are summarized as well.

Original languageEnglish
Pages (from-to)1-24
Number of pages24
JournalEuropean Biophysics Journal
DOIs
Publication statusAccepted/In press - Jun 16 2016

Fingerprint

Nanomedicine
Polyphenols
Tea
Clinical Trials
Proteins
Artemisia annua
Nobel Prize
Chinese Traditional Medicine
Traditional Medicine
Cell Adhesion
Nanoparticles
Malaria
Cell Movement
Theoretical Models
Animal Models
Cell Culture Techniques
Antioxidants
Research Personnel
Apoptosis
Cell Line

Keywords

  • Anticancer effects
  • Cell adhesion
  • EGCg
  • Nanoparticles
  • Polyphenol
  • Proteins

ASJC Scopus subject areas

  • Biophysics

Cite this

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AU - Bősze, Sz.

AU - Horváth, R.

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