Biopharmaceutical investigation of fenoprofen.

E. Kéri, S. Marton, J. Plachy, I. Rácz

Research output: Contribution to journalArticle

Abstract

The salts of fenoprofen formed with different metals have shown various crystal forms and solubility. The calcium salt has proved the most suitable characteristics for tablet and capsule production. Dissolution and absorption parameters of this substance were studied using in vitro and in vivo methods. The absorption rate and the correlation between pH and membrane diffusion rate constant were investigated in vitro using the "Sartorius" apparatus. The dissolution rate--depending on pH--was investigated by the oscillometric method. The in vivo disintegration of an experimental sample was compared with a commercial preparation. The comparison has been documented by endoscopic photography.

Original languageEnglish
Pages (from-to)30-32
Number of pages3
JournalPharmazie
Volume42
Issue number1
Publication statusPublished - Jan 1987

Fingerprint

Fenoprofen
Dissolution
Salts
Disintegration
Photography
Solubility
Tablets
Capsules
Rate constants
Metals
Calcium
Membranes
Crystals
In Vitro Techniques

ASJC Scopus subject areas

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

Kéri, E., Marton, S., Plachy, J., & Rácz, I. (1987). Biopharmaceutical investigation of fenoprofen. Pharmazie, 42(1), 30-32.

Biopharmaceutical investigation of fenoprofen. / Kéri, E.; Marton, S.; Plachy, J.; Rácz, I.

In: Pharmazie, Vol. 42, No. 1, 01.1987, p. 30-32.

Research output: Contribution to journalArticle

Kéri, E, Marton, S, Plachy, J & Rácz, I 1987, 'Biopharmaceutical investigation of fenoprofen.', Pharmazie, vol. 42, no. 1, pp. 30-32.
Kéri E, Marton S, Plachy J, Rácz I. Biopharmaceutical investigation of fenoprofen. Pharmazie. 1987 Jan;42(1):30-32.
Kéri, E. ; Marton, S. ; Plachy, J. ; Rácz, I. / Biopharmaceutical investigation of fenoprofen. In: Pharmazie. 1987 ; Vol. 42, No. 1. pp. 30-32.
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