Biological therapy in inflammatory bowel diseases: Access in Central and Eastern Europe

Fanni Rencz, Márta Péntek, Martin Bortlik, Edyta Zagorowicz, Tibor Hlavaty, Andrzej ͆liwczyński, Mihai M. Diculescu, Limas Kupcinskas, Krisztina B. Gecse, László Gulácsi, Peter L. Lakatos

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Abstract

Biological drugs opened up new horizons in the management of inflammatory bowel diseases (IBD). This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European (CEE) countries, namely Bulgaria, the Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania and Slovakia. Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed. Moreover, we provide an estimation on prevalence of IBD as well as biological treatment rates. In all countries with the exception of Romania, lower biological treatment rates were observed in ulcerative colitis (UC) compared to Crohn's disease despite the higher prevalence of UC. Great heterogeneity (up to 96-fold) was found in access to biologicals across the CEE countries. Poland, Bulgaria, Romania and the Baltic States are lagging behind Hungary, Slovakia and the Czech Republic in their access to biologicals. Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria, Latvia, Lithuania, and Poland, but association with other possible determinants (differences in prevalence and incidence, price of biologicals, total expenditure on health, geographical access, and cost-effectiveness results) was not proven. We assume, nevertheless, that health deterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD. In conclusion, access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors, drug prices or total health expenditure. Changes in reimbursement policy could contribute to better access to biologicals in some countries.

Original languageEnglish
Pages (from-to)1728-1737
Number of pages10
JournalWorld journal of gastroenterology
Volume21
Issue number6
DOIs
Publication statusPublished - Feb 14 2015

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Keywords

  • Access
  • Biological therapy
  • Crohn's disease
  • Europe, Central and Eastern
  • Inflammatory bowel diseases
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Rencz, F., Péntek, M., Bortlik, M., Zagorowicz, E., Hlavaty, T., ͆liwczyński, A., Diculescu, M. M., Kupcinskas, L., Gecse, K. B., Gulácsi, L., & Lakatos, P. L. (2015). Biological therapy in inflammatory bowel diseases: Access in Central and Eastern Europe. World journal of gastroenterology, 21(6), 1728-1737. https://doi.org/10.3748/wjg.v21.i6.1728