Biological therapy and surgery rates in inflammatory bowel diseases – Data analysis of almost 1000 patients from a Hungarian tertiary IBD center

Kata Szántó, T. Nyári, Anita Bálint, Renáta Bor, Ágnes Milassin, Mariann Rutka, Anna Fábián, Zoltán Szepes, Ferenc Nagy, T. Molnár, Klaudia Farkas

Research output: Contribution to journalArticle

Abstract

Inflammatory bowel diseases (IBD) [Crohn’s disease (CD) and ulcerative colitis (UC)], are chronic relapsing disorders of unknown etiology. The aim of this study was to determine demographic features, disease phenotypes, medical and surgical therapies in our IBD patients and to identify which parameters are in association with the need of surgery and/or biologic therapy. Data on demographic and clinical characteristics of the patients were analyzed from the IBD registry of the 1st Department of Medicine, University of Szeged. The study period was between January 2007 and March 2015. Data of 911 IBD patients (428 CD, 483 UC) were analyzed. The median lag time between onset of symptoms and diagnosis proved to be significantly longer in UC than in CD (4.6 years vs. 2.1 years, p = 0.01). 40% of the patients received biological therapy, 301 patients underwent surgery required more frequently for CD than UC. Surgery was more common in CD patients with ileal location and penetrating behaviour. In UC, more severe disease onset predicted to unfavourable disease course. Higher proportion of surgery was shown in patient aged above 40 years in both CD and UC. Diagnostic delay of more than 1 year and appendectomy predicted to unfavourable disease outcome of both CD and UC. This analysis revealed that more than 1 year of diagnostic delay, disease activity at diagnosis in UC, CD, ileal location and penetrating behaviour are factors that may influence disease outcome. Use of thiopurines seemed to be protective in UC.

Original languageEnglish
Article numbere0200824
JournalPLoS One
Volume13
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

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Biological Therapy
inflammatory bowel disease
colitis
Crohn disease
Ulcerative Colitis
Inflammatory Bowel Diseases
Surgery
Crohn Disease
data analysis
surgery
therapeutics
demographic statistics
Demography
Appendectomy
disease course
signs and symptoms (animals and humans)
etiology
Registries
medicine
Medicine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Biological therapy and surgery rates in inflammatory bowel diseases – Data analysis of almost 1000 patients from a Hungarian tertiary IBD center. / Szántó, Kata; Nyári, T.; Bálint, Anita; Bor, Renáta; Milassin, Ágnes; Rutka, Mariann; Fábián, Anna; Szepes, Zoltán; Nagy, Ferenc; Molnár, T.; Farkas, Klaudia.

In: PLoS One, Vol. 13, No. 7, e0200824, 01.07.2018.

Research output: Contribution to journalArticle

Szántó, Kata ; Nyári, T. ; Bálint, Anita ; Bor, Renáta ; Milassin, Ágnes ; Rutka, Mariann ; Fábián, Anna ; Szepes, Zoltán ; Nagy, Ferenc ; Molnár, T. ; Farkas, Klaudia. / Biological therapy and surgery rates in inflammatory bowel diseases – Data analysis of almost 1000 patients from a Hungarian tertiary IBD center. In: PLoS One. 2018 ; Vol. 13, No. 7.
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