Biological significance of protein modifications in aging and calorie restriction

Akihiro Nakamura, Kyojiro Kawakami, Fuyuki Kametani, Hideko Nakamoto, S. Goto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

31 Citations (Scopus)

Abstract

By virtue of the progress in proteomics, the involvement of posttranslational modifications in aging has been more clearly demonstrated in recent years. We describe here that (1) carbonylation, a hallmark of protein oxidation in general, is paradoxically decreased in histone with aging and increased by calorie restriction (CR), (2) acetylation of lysine 9 and phosphorylation of serine 10 in histone H3 are decreased and increased, respectively, with aging, and (3) the acetylation level of multiple extranuclear proteins decreases significantly with aging, and the change was not only retarded but increased remarkably by CR in rat liver. Based on these findings, we discuss possible implications of the posttranslational protein modifications in biochemical processes underlying aging and CR-induced extension of life span.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages33-39
Number of pages7
Volume1197
DOIs
Publication statusPublished - Jun 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1197
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Aging of materials
Post Translational Protein Processing
Acetylation
Histones
Biochemical Phenomena
Proteins
Life Expectancy
Proteomics
Serine
Lysine
Carbonylation
Phosphorylation
Liver
Rats
Oxidation

Keywords

  • Acetylation
  • Carbonylation
  • Epigenetics
  • Histones

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nakamura, A., Kawakami, K., Kametani, F., Nakamoto, H., & Goto, S. (2010). Biological significance of protein modifications in aging and calorie restriction. In Annals of the New York Academy of Sciences (Vol. 1197, pp. 33-39). (Annals of the New York Academy of Sciences; Vol. 1197). https://doi.org/10.1111/j.1749-6632.2009.05374.x

Biological significance of protein modifications in aging and calorie restriction. / Nakamura, Akihiro; Kawakami, Kyojiro; Kametani, Fuyuki; Nakamoto, Hideko; Goto, S.

Annals of the New York Academy of Sciences. Vol. 1197 2010. p. 33-39 (Annals of the New York Academy of Sciences; Vol. 1197).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nakamura, A, Kawakami, K, Kametani, F, Nakamoto, H & Goto, S 2010, Biological significance of protein modifications in aging and calorie restriction. in Annals of the New York Academy of Sciences. vol. 1197, Annals of the New York Academy of Sciences, vol. 1197, pp. 33-39. https://doi.org/10.1111/j.1749-6632.2009.05374.x
Nakamura A, Kawakami K, Kametani F, Nakamoto H, Goto S. Biological significance of protein modifications in aging and calorie restriction. In Annals of the New York Academy of Sciences. Vol. 1197. 2010. p. 33-39. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2009.05374.x
Nakamura, Akihiro ; Kawakami, Kyojiro ; Kametani, Fuyuki ; Nakamoto, Hideko ; Goto, S. / Biological significance of protein modifications in aging and calorie restriction. Annals of the New York Academy of Sciences. Vol. 1197 2010. pp. 33-39 (Annals of the New York Academy of Sciences).
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