Biological significance of protein modifications in aging and calorie restriction

Akihiro Nakamura, Kyojiro Kawakami, Fuyuki Kametani, Hideko Nakamoto, Sataro Goto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

32 Citations (Scopus)


By virtue of the progress in proteomics, the involvement of posttranslational modifications in aging has been more clearly demonstrated in recent years. We describe here that (1) carbonylation, a hallmark of protein oxidation in general, is paradoxically decreased in histone with aging and increased by calorie restriction (CR), (2) acetylation of lysine 9 and phosphorylation of serine 10 in histone H3 are decreased and increased, respectively, with aging, and (3) the acetylation level of multiple extranuclear proteins decreases significantly with aging, and the change was not only retarded but increased remarkably by CR in rat liver. Based on these findings, we discuss possible implications of the posttranslational protein modifications in biochemical processes underlying aging and CR-induced extension of life span.

Original languageEnglish
Title of host publicationAging, Cancer, and Age-Related Diseases
Subtitle of host publicationCommon Mechanisms
PublisherBlackwell Publishing Inc.
Number of pages7
ISBN (Print)9781573317962
Publication statusPublished - Jun 2010

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Acetylation
  • Carbonylation
  • Epigenetics
  • Histones

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Nakamura, A., Kawakami, K., Kametani, F., Nakamoto, H., & Goto, S. (2010). Biological significance of protein modifications in aging and calorie restriction. In Aging, Cancer, and Age-Related Diseases: Common Mechanisms (pp. 33-39). (Annals of the New York Academy of Sciences; Vol. 1197). Blackwell Publishing Inc..