Biological significance of methylated derivatives of lysine and Arginine

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Abstract

It has been shown by biological trials that L-lysine and L-arginine are essential for the undisturbed growth of living organisms. These amino acids show different reactivity in the molecular processes of the cell which explains their antagonistic function. As a result of enzymatic methylation the N-ε{lunate} as well as NG-methylated derivatives of lysine and arginine are produced. The biological function of the methylated basic amino acids is almost unknown. Some N-ε{lunate}-methylated lysines, but first of all N-ε{lunate}-trimethyl lysine /TML/ exhibits a proliferation promoting effect on several normal and neoplastic cell systems. NG-methylated arginines proved to have a proliferation inhibiting effect. Thus, methylation of basic amino acids may have a special significance in the regulation of cell proliferation.

Original languageEnglish
Pages (from-to)385-392
Number of pages8
JournalLife Sciences
Volume20
Issue number3
DOIs
Publication statusPublished - Feb 1 1977

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Lysine
Arginine
Derivatives
Basic Amino Acids
Methylation
Cell proliferation
Cell Proliferation
Amino Acids
Growth

ASJC Scopus subject areas

  • Pharmacology

Cite this

Biological significance of methylated derivatives of lysine and Arginine. / Tyihák, E.; Szende, B.; Lapis, K.

In: Life Sciences, Vol. 20, No. 3, 01.02.1977, p. 385-392.

Research output: Contribution to journalArticle

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