Biological properties of Aujeszky's disease (pseudorabies) virus strains with special regard to interferon production and interferon sensitivity

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The avirulent strain KF of Aujeszky's disease (pseudorabies) virus had a 10 to 100 times lower growth ability in chick embryo fibroblast cells than the virulent strain and it formed scarcely visible plaques, if any. Infection of permanent pig kidney cells (PK15) with avirulent strains resulted in higher virus yields than the virulent strain and easily visible, small plaques (0.5 mm) arose. The virulent strain formed plaques about 2 mm in diameter in both types of cells. The avirulent strains were not neuropathogenic for the chick, whereas the virulent strains showed a distinct neurovirulence. The avirulent strains stimulate a small amount of interferon in chick embryo fibroblast cultures from about 30 hours after infection and are 5-10 times more sensitive to interferon than the virulent strains.

Original languageEnglish
Pages (from-to)205-214
Number of pages10
JournalArchiv für die gesamte Virusforschung
Volume44
Issue number3
DOIs
Publication statusPublished - Sep 1974

Fingerprint

Suid Herpesvirus 1
Interferons
Chick Embryo
Fibroblasts
Infection
Swine
Viruses
Kidney
Growth

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics

Cite this

@article{ace79baeaad145b190ba399cd8054173,
title = "Biological properties of Aujeszky's disease (pseudorabies) virus strains with special regard to interferon production and interferon sensitivity",
abstract = "The avirulent strain KF of Aujeszky's disease (pseudorabies) virus had a 10 to 100 times lower growth ability in chick embryo fibroblast cells than the virulent strain and it formed scarcely visible plaques, if any. Infection of permanent pig kidney cells (PK15) with avirulent strains resulted in higher virus yields than the virulent strain and easily visible, small plaques (0.5 mm) arose. The virulent strain formed plaques about 2 mm in diameter in both types of cells. The avirulent strains were not neuropathogenic for the chick, whereas the virulent strains showed a distinct neurovirulence. The avirulent strains stimulate a small amount of interferon in chick embryo fibroblast cultures from about 30 hours after infection and are 5-10 times more sensitive to interferon than the virulent strains.",
author = "B. Lomniczi",
year = "1974",
month = "9",
doi = "10.1007/BF01240608",
language = "English",
volume = "44",
pages = "205--214",
journal = "Archives of Virology",
issn = "0304-8608",
publisher = "Springer Wien",
number = "3",

}

TY - JOUR

T1 - Biological properties of Aujeszky's disease (pseudorabies) virus strains with special regard to interferon production and interferon sensitivity

AU - Lomniczi, B.

PY - 1974/9

Y1 - 1974/9

N2 - The avirulent strain KF of Aujeszky's disease (pseudorabies) virus had a 10 to 100 times lower growth ability in chick embryo fibroblast cells than the virulent strain and it formed scarcely visible plaques, if any. Infection of permanent pig kidney cells (PK15) with avirulent strains resulted in higher virus yields than the virulent strain and easily visible, small plaques (0.5 mm) arose. The virulent strain formed plaques about 2 mm in diameter in both types of cells. The avirulent strains were not neuropathogenic for the chick, whereas the virulent strains showed a distinct neurovirulence. The avirulent strains stimulate a small amount of interferon in chick embryo fibroblast cultures from about 30 hours after infection and are 5-10 times more sensitive to interferon than the virulent strains.

AB - The avirulent strain KF of Aujeszky's disease (pseudorabies) virus had a 10 to 100 times lower growth ability in chick embryo fibroblast cells than the virulent strain and it formed scarcely visible plaques, if any. Infection of permanent pig kidney cells (PK15) with avirulent strains resulted in higher virus yields than the virulent strain and easily visible, small plaques (0.5 mm) arose. The virulent strain formed plaques about 2 mm in diameter in both types of cells. The avirulent strains were not neuropathogenic for the chick, whereas the virulent strains showed a distinct neurovirulence. The avirulent strains stimulate a small amount of interferon in chick embryo fibroblast cultures from about 30 hours after infection and are 5-10 times more sensitive to interferon than the virulent strains.

UR - http://www.scopus.com/inward/record.url?scp=34250412488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250412488&partnerID=8YFLogxK

U2 - 10.1007/BF01240608

DO - 10.1007/BF01240608

M3 - Article

VL - 44

SP - 205

EP - 214

JO - Archives of Virology

JF - Archives of Virology

SN - 0304-8608

IS - 3

ER -