Biological half-life and organ distribution of [3H]1-deamino-8-D-arginine-vasopressin in the rat

F. László, T. Janáky, L. Balaspiri, J. L. Morgat

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The biological half-life of synthetic, radiochemically pure, biologically active [3H]1-deamino-8-D-arginine-vasopressin (dDAVP) in rats was found to be 5.33 ± 0.28 (S.E.M.) min in the initial, transitional, fast phase and 56.28 ± 3.27 min in the second, slow phase. The substance accumulated to the greatest extent in the kidney and small intestine and only slightly in the adenohypophysis. The results have suggested that the extended biological half-life may play a role in the more marked and longer antidiuretic effect of dDAVP. The explanation of the poor accumulation in the adenohypophysis may be that dDAVP does not possess an effect similar to that of corticotrophin releasing factor.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalJournal of Endocrinology
Volume88
Issue number2
Publication statusPublished - 1981

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Deamino Arginine Vasopressin
Anterior Pituitary Gland
Arginine Vasopressin
Half-Life
Antidiuretic Agents
Corticotropin-Releasing Hormone
Small Intestine
Kidney

ASJC Scopus subject areas

  • Endocrinology

Cite this

Biological half-life and organ distribution of [3H]1-deamino-8-D-arginine-vasopressin in the rat. / László, F.; Janáky, T.; Balaspiri, L.; Morgat, J. L.

In: Journal of Endocrinology, Vol. 88, No. 2, 1981, p. 181-186.

Research output: Contribution to journalArticle

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