Biological functions of the WAP domain-containing multidomain proteins WFIKKN1 and WFIKKN2

Katalin Kondás, Gyor̈gy Szlaḿa, Alinda Nagy, M. Trexler, L. Patthy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

WFIKKN1 and WFIKKN2 are two closely related multidomain proteins consisting of a WAP (whey acidic protein)-, a follistatin-, an immunoglobulin-, two Kunitz-type protease inhibitor-domains and an NTR domain (netrin domain). Recent experiments have shown that both WFIKKN1 and WFIKKN2 bind myostatin and GDF11 (growth and differentiation factor 11) with high affinity and are potent antagonists of these growth factors. Structure-function studies on WFIKKN proteins have revealed that their interactions with GDF8 and GDF11 are mediated primarily by the follistatin and NTR domains.

Original languageEnglish
Pages (from-to)1416-1420
Number of pages5
JournalBiochemical Society Transactions
Volume39
Issue number5
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Growth Differentiation Factors
Follistatin
Myostatin
Protease Inhibitors
Immunoglobulins
Intercellular Signaling Peptides and Proteins
Proteins
Experiments
whey acidic proteins
Protein Domains

Keywords

  • Growth and differentiation factor 11 (GDF11)
  • Growth factor antagonist
  • Myostatin
  • Protease inhibitor
  • Transforming growth factor β (TGFβ)
  • WFIKKN

ASJC Scopus subject areas

  • Biochemistry

Cite this

Biological functions of the WAP domain-containing multidomain proteins WFIKKN1 and WFIKKN2. / Kondás, Katalin; Szlaḿa, Gyor̈gy; Nagy, Alinda; Trexler, M.; Patthy, L.

In: Biochemical Society Transactions, Vol. 39, No. 5, 10.2011, p. 1416-1420.

Research output: Contribution to journalArticle

Kondás, Katalin ; Szlaḿa, Gyor̈gy ; Nagy, Alinda ; Trexler, M. ; Patthy, L. / Biological functions of the WAP domain-containing multidomain proteins WFIKKN1 and WFIKKN2. In: Biochemical Society Transactions. 2011 ; Vol. 39, No. 5. pp. 1416-1420.
@article{0e1f4d420e2f41b79e6111ddb6b7ae5b,
title = "Biological functions of the WAP domain-containing multidomain proteins WFIKKN1 and WFIKKN2",
abstract = "WFIKKN1 and WFIKKN2 are two closely related multidomain proteins consisting of a WAP (whey acidic protein)-, a follistatin-, an immunoglobulin-, two Kunitz-type protease inhibitor-domains and an NTR domain (netrin domain). Recent experiments have shown that both WFIKKN1 and WFIKKN2 bind myostatin and GDF11 (growth and differentiation factor 11) with high affinity and are potent antagonists of these growth factors. Structure-function studies on WFIKKN proteins have revealed that their interactions with GDF8 and GDF11 are mediated primarily by the follistatin and NTR domains.",
keywords = "Growth and differentiation factor 11 (GDF11), Growth factor antagonist, Myostatin, Protease inhibitor, Transforming growth factor β (TGFβ), WFIKKN",
author = "Katalin Kond{\'a}s and Gyor̈gy Szlaḿa and Alinda Nagy and M. Trexler and L. Patthy",
year = "2011",
month = "10",
doi = "10.1042/BST0391416",
language = "English",
volume = "39",
pages = "1416--1420",
journal = "Biochemical Society Transactions",
issn = "0300-5127",
publisher = "Portland Press Ltd.",
number = "5",

}

TY - JOUR

T1 - Biological functions of the WAP domain-containing multidomain proteins WFIKKN1 and WFIKKN2

AU - Kondás, Katalin

AU - Szlaḿa, Gyor̈gy

AU - Nagy, Alinda

AU - Trexler, M.

AU - Patthy, L.

PY - 2011/10

Y1 - 2011/10

N2 - WFIKKN1 and WFIKKN2 are two closely related multidomain proteins consisting of a WAP (whey acidic protein)-, a follistatin-, an immunoglobulin-, two Kunitz-type protease inhibitor-domains and an NTR domain (netrin domain). Recent experiments have shown that both WFIKKN1 and WFIKKN2 bind myostatin and GDF11 (growth and differentiation factor 11) with high affinity and are potent antagonists of these growth factors. Structure-function studies on WFIKKN proteins have revealed that their interactions with GDF8 and GDF11 are mediated primarily by the follistatin and NTR domains.

AB - WFIKKN1 and WFIKKN2 are two closely related multidomain proteins consisting of a WAP (whey acidic protein)-, a follistatin-, an immunoglobulin-, two Kunitz-type protease inhibitor-domains and an NTR domain (netrin domain). Recent experiments have shown that both WFIKKN1 and WFIKKN2 bind myostatin and GDF11 (growth and differentiation factor 11) with high affinity and are potent antagonists of these growth factors. Structure-function studies on WFIKKN proteins have revealed that their interactions with GDF8 and GDF11 are mediated primarily by the follistatin and NTR domains.

KW - Growth and differentiation factor 11 (GDF11)

KW - Growth factor antagonist

KW - Myostatin

KW - Protease inhibitor

KW - Transforming growth factor β (TGFβ)

KW - WFIKKN

UR - http://www.scopus.com/inward/record.url?scp=80053362700&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053362700&partnerID=8YFLogxK

U2 - 10.1042/BST0391416

DO - 10.1042/BST0391416

M3 - Article

VL - 39

SP - 1416

EP - 1420

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 5

ER -