Biological function of Lemur tyrosine kinase 2 (LMTK2): Implications in neurodegeneration

János Bencze, Gábor Miklós Mórotz, Woosung Seo, Viktor Bencs, J. Kálmán, Christopher Charles John Miller, T. Hortobágyi

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Neurodegenerative disorders are frequent, incurable diseases characterised by abnormal protein accumulation and progressive neuronal loss. Despite their growing prevalence, the underlying pathomechanism remains unclear. Lemur tyrosine kinase 2 (LMTK2) is a member of a transmembrane serine/threonine-protein kinase family. Although it was described more than a decade ago, our knowledge on LMTK2's biological functions is still insufficient. Recent evidence has suggested that LMTK2 is implicated in neurodegeneration. After reviewing the literature, we identified three LMTK2-mediated mechanisms which may contribute to neurodegenerative processes: disrupted axonal transport, tau hyperphosphorylation and enhanced apoptosis. Moreover, LMTK2 gene expression is decreased in an Alzheimer's disease mouse model. According to these features, LMTK2 might be a promising therapeutic target in near future. However, further investigations are required to clarify the exact biological functions of this unique protein.

Original languageEnglish
Article number20
JournalMolecular Brain
Volume11
Issue number1
DOIs
Publication statusPublished - Apr 10 2018

Fingerprint

Lemur
TYK2 Kinase
Axonal Transport
Protein-Serine-Threonine Kinases
Neurodegenerative Diseases
Alzheimer Disease
Proteins
Apoptosis
Gene Expression

Keywords

  • Alzheimer's disease
  • Axonal transport
  • LMTK2
  • Neurodegeneration
  • Tau

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Biological function of Lemur tyrosine kinase 2 (LMTK2) : Implications in neurodegeneration. / Bencze, János; Mórotz, Gábor Miklós; Seo, Woosung; Bencs, Viktor; Kálmán, J.; Miller, Christopher Charles John; Hortobágyi, T.

In: Molecular Brain, Vol. 11, No. 1, 20, 10.04.2018.

Research output: Contribution to journalReview article

Bencze, János ; Mórotz, Gábor Miklós ; Seo, Woosung ; Bencs, Viktor ; Kálmán, J. ; Miller, Christopher Charles John ; Hortobágyi, T. / Biological function of Lemur tyrosine kinase 2 (LMTK2) : Implications in neurodegeneration. In: Molecular Brain. 2018 ; Vol. 11, No. 1.
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