Biological evaluation of bishydroxymethyl-substituted cage dimeric 1,4-dihydropyridines as a novel class of P-glycoprotein modulating agents in cancer cells

Martin Richter, Jósef Molnár, Andreas Hilgeroth

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A series of N-substituted cage dimeric 1,4-dihydropyridines 3a-e was evaluated as inhibitors of membrane efflux pump P-glycoprotein (P-gp) in multidrug resistant (mdr) cancer cells. Structure-activity relationships (SAR) and cytotoxic properties are discussed. Effective concentrations for overcoming mdr have been demonstrated in competition studies with the P-gp substrate epirubicin.

Original languageEnglish
Pages (from-to)2838-2840
Number of pages3
JournalJournal of Medicinal Chemistry
Volume49
Issue number9
DOIs
Publication statusPublished - May 4 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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