Biological effect of p(18 MeV)+Be Fast neutrons

A. M. Dám, L. G. Gazsó, M. Rétlaki, A. Fenyvesi, T. Molnár

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The application of fast neutrons in radiotherapy has been stimulated by the expectation that, in comparison with low LET radiations, differences in radiobiological factors might result in a larger relative biological effectiveness (RBE) and lower oxygen enhancement ratio (OER). The biological effects of a mixed neutron-gamma field, due to the nuclear physics reaction, depend on the physical parameters (energy spectra, fluxes, fluences, etc.) of the component of the radiation determined by the facility and the high LET particle used, releasing from the nuclear reaction. Accepting that the biological effects of the low and high LET radiation are different the knowledge of the most important RBE and OER values is critical in application of fast neutron irradiation facility for radiobiological research and therapeutical purpose. Basic radiobiological study was carried out at the MGC-20E Cyclotron of ATOM-KI (Debrecen). RBE and OER were determined for survival of bacterial (E. coli B/r) and mammalian cells (CHO), using60Co ψ-rays as a reference radiation. RBE was found 2.46 for E. coli and 5.1 for CHO cells. The calculation of OER resulted in a lower value by about 60%, than it was obtained with gamma radiation (gamma=2.1 neutrons=1.31). Reduced effectiveness was found for different chemical modifying agents such as thiol reactive, radiosensitizing, radioprotecting compounds, compared to ψ-radiations, which was due to the differences in the radiochemical processes at high LET radiation. *** DIRECT SUPPORT *** A01PS043 00017

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalActa Physica Hungarica
Issue number1-4
Publication statusPublished - Dec 1 1994

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    Dám, A. M., Gazsó, L. G., Rétlaki, M., Fenyvesi, A., & Molnár, T. (1994). Biological effect of p(18 MeV)+Be Fast neutrons. Acta Physica Hungarica, 75(1-4), 321-324.