Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice

Research output: Contribution to journalReview article

85 Citations (Scopus)

Abstract

Originally described as the signal-transducing pathway of interferons, the JAK-STAT pathway soon turned out to participate in the signalling of numerous other immune and even non-immune mediators. Several murine knockout models have been described that underline the biological significance of this signalling system. Some human diseases (mainly neoplastic) are also known where malfunctioning of the JAK-STAT pathway is considered to participate in the pathogenesis. In this brief review article we will try to make a synopsis of its biological and clinical significance.

Original languageEnglish
Pages (from-to)435-441
Number of pages7
JournalInflammation Research
Volume50
Issue number9
DOIs
Publication statusPublished - Jan 1 2001

    Fingerprint

Keywords

  • Cytokine
  • JAK-STAT
  • Knockout
  • SOCS

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this