Biological activity of persimmon (Diospyros kaki) peel extracts

Masami Kawase, Noboru Motohashi, Kazue Satoh, Hiroshi Sakagami, Hideki Nakashima, Satoru Tani, Yoshiaki Shirataki, Teruo Kurihara, G. Spengler, Krisztina Wolfard, J. Molnár

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Fractionated extracts of persimmon (Diospyros kaki) peels were studied for cytotoxic activity, multidrug resistance (MDR) reversal activity, anti-human immunodeficiency virus (HIV) activity and anti-Helicobacter pylori (H. pylori) activity. The potent cytotoxic activity against human oral squamous cell carcinoma cells (HSC-2) and human submandibular gland tumor (HSG) cells was found in the acetone fractions (A4 and A5) with IC50 ranging from 21 to 59 μg/mL. However, the cytotoxic activity was not correlated with the radical intensity of the fractions. Three 70% MeOH extract fractions (70M2-4) produced radical and efficiently scavenged the O2- produced by hypoxanthine and xanthine oxidase reaction. All of the fractions tested were not effective for anti-H. pylori and anti-HIV. Fractions H3 and H4 of hexane extract, and M2 and M3 of MeOH extract showed a remarkable MDR reversal activity comparable with that of (±)-verapamil (a positive control). These results indicate the therapeutic value of persimmon peel extracts as potential antitumor and MDR-reversing agents.

Original languageEnglish
Pages (from-to)495-500
Number of pages6
JournalPhytotherapy Research
Volume17
Issue number5
DOIs
Publication statusPublished - May 2003

Fingerprint

Diospyros
Multiple Drug Resistance
Bioactivity
Viruses
Cells
Helicobacter pylori
Xanthine Oxidase
Hexanes
Verapamil
Acetone
HIV
Tumors
Submandibular Gland
Human Activities
Inhibitory Concentration 50
Squamous Cell Carcinoma
Neoplasms
Therapeutics

Keywords

  • Cytotoxic activity
  • Diospyros
  • Ebenaceae
  • Kaki
  • MDR
  • Persimmon peel
  • Radical intensity

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Kawase, M., Motohashi, N., Satoh, K., Sakagami, H., Nakashima, H., Tani, S., ... Molnár, J. (2003). Biological activity of persimmon (Diospyros kaki) peel extracts. Phytotherapy Research, 17(5), 495-500. https://doi.org/10.1002/ptr.1183

Biological activity of persimmon (Diospyros kaki) peel extracts. / Kawase, Masami; Motohashi, Noboru; Satoh, Kazue; Sakagami, Hiroshi; Nakashima, Hideki; Tani, Satoru; Shirataki, Yoshiaki; Kurihara, Teruo; Spengler, G.; Wolfard, Krisztina; Molnár, J.

In: Phytotherapy Research, Vol. 17, No. 5, 05.2003, p. 495-500.

Research output: Contribution to journalArticle

Kawase, M, Motohashi, N, Satoh, K, Sakagami, H, Nakashima, H, Tani, S, Shirataki, Y, Kurihara, T, Spengler, G, Wolfard, K & Molnár, J 2003, 'Biological activity of persimmon (Diospyros kaki) peel extracts', Phytotherapy Research, vol. 17, no. 5, pp. 495-500. https://doi.org/10.1002/ptr.1183
Kawase M, Motohashi N, Satoh K, Sakagami H, Nakashima H, Tani S et al. Biological activity of persimmon (Diospyros kaki) peel extracts. Phytotherapy Research. 2003 May;17(5):495-500. https://doi.org/10.1002/ptr.1183
Kawase, Masami ; Motohashi, Noboru ; Satoh, Kazue ; Sakagami, Hiroshi ; Nakashima, Hideki ; Tani, Satoru ; Shirataki, Yoshiaki ; Kurihara, Teruo ; Spengler, G. ; Wolfard, Krisztina ; Molnár, J. / Biological activity of persimmon (Diospyros kaki) peel extracts. In: Phytotherapy Research. 2003 ; Vol. 17, No. 5. pp. 495-500.
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