Biological activity of kiwifruit peel extracts

Masami Kawase, Noboru Motohashi, Kazue Satoh, Hiroshi Sakagami, Hideki Nakashima, Satoru Tani, Yoshiaki Shirataki, Teruo Kurihara, G. Spengler, Krisztina Wolfard, J. Molnár

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Various bioactive substances in kiwifruit extracts were fractionated by organic solvent extractions, followed by silica gel and ODS chromatographies. Both cytotoxic activity and multi-drug resistance reversal activity were found in the less polar fractions. Cytotoxic activity was not always parallel the radical intensity. Antibacterial activity was distributed into various fractions and all fractions were inactive against Candida albicans and H. pylori. Only 70% methanol extracts showed anti-human immunodeficiency virus activity, and produced a broad ESR signal under alkaline conditions, in a fashion similar to lignin. These fractions also effectively scavenged O2- produced by the xanthine-xanthine oxidase reaction, suggesting a bimodal (pro-oxidant and antioxidant) action. These data suggest a medicinal efficacy of kiwifruit peel extracts.

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalPhytotherapy Research
Volume15
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

Xanthine
Xanthine Oxidase
Candida
Lignin
Pylorus
Silica Gel
Multiple Drug Resistance
Solvent extraction
Chromatography
Bioactivity
Candida albicans
Viruses
Organic solvents
Gel Chromatography
Paramagnetic resonance
Methanol
Reactive Oxygen Species
Antioxidants
HIV
Pharmaceutical Preparations

Keywords

  • Actinidia deliciosa
  • Actinidiaceae
  • Anti-HIV activity
  • Cytotoxic activity
  • Fractionation
  • Kiwifruit peel extracts
  • Radical intensity

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Kawase, M., Motohashi, N., Satoh, K., Sakagami, H., Nakashima, H., Tani, S., ... Molnár, J. (2001). Biological activity of kiwifruit peel extracts. Phytotherapy Research, 15(4), 337-343. https://doi.org/10.1002/ptr.876

Biological activity of kiwifruit peel extracts. / Kawase, Masami; Motohashi, Noboru; Satoh, Kazue; Sakagami, Hiroshi; Nakashima, Hideki; Tani, Satoru; Shirataki, Yoshiaki; Kurihara, Teruo; Spengler, G.; Wolfard, Krisztina; Molnár, J.

In: Phytotherapy Research, Vol. 15, No. 4, 2001, p. 337-343.

Research output: Contribution to journalArticle

Kawase, M, Motohashi, N, Satoh, K, Sakagami, H, Nakashima, H, Tani, S, Shirataki, Y, Kurihara, T, Spengler, G, Wolfard, K & Molnár, J 2001, 'Biological activity of kiwifruit peel extracts', Phytotherapy Research, vol. 15, no. 4, pp. 337-343. https://doi.org/10.1002/ptr.876
Kawase M, Motohashi N, Satoh K, Sakagami H, Nakashima H, Tani S et al. Biological activity of kiwifruit peel extracts. Phytotherapy Research. 2001;15(4):337-343. https://doi.org/10.1002/ptr.876
Kawase, Masami ; Motohashi, Noboru ; Satoh, Kazue ; Sakagami, Hiroshi ; Nakashima, Hideki ; Tani, Satoru ; Shirataki, Yoshiaki ; Kurihara, Teruo ; Spengler, G. ; Wolfard, Krisztina ; Molnár, J. / Biological activity of kiwifruit peel extracts. In: Phytotherapy Research. 2001 ; Vol. 15, No. 4. pp. 337-343.
@article{fc9445eea3bc405b96a08111bb398d1c,
title = "Biological activity of kiwifruit peel extracts",
abstract = "Various bioactive substances in kiwifruit extracts were fractionated by organic solvent extractions, followed by silica gel and ODS chromatographies. Both cytotoxic activity and multi-drug resistance reversal activity were found in the less polar fractions. Cytotoxic activity was not always parallel the radical intensity. Antibacterial activity was distributed into various fractions and all fractions were inactive against Candida albicans and H. pylori. Only 70{\%} methanol extracts showed anti-human immunodeficiency virus activity, and produced a broad ESR signal under alkaline conditions, in a fashion similar to lignin. These fractions also effectively scavenged O2- produced by the xanthine-xanthine oxidase reaction, suggesting a bimodal (pro-oxidant and antioxidant) action. These data suggest a medicinal efficacy of kiwifruit peel extracts.",
keywords = "Actinidia deliciosa, Actinidiaceae, Anti-HIV activity, Cytotoxic activity, Fractionation, Kiwifruit peel extracts, Radical intensity",
author = "Masami Kawase and Noboru Motohashi and Kazue Satoh and Hiroshi Sakagami and Hideki Nakashima and Satoru Tani and Yoshiaki Shirataki and Teruo Kurihara and G. Spengler and Krisztina Wolfard and J. Moln{\'a}r",
year = "2001",
doi = "10.1002/ptr.876",
language = "English",
volume = "15",
pages = "337--343",
journal = "Phytotherapy Research",
issn = "0951-418X",
publisher = "John Wiley and Sons Ltd",
number = "4",

}

TY - JOUR

T1 - Biological activity of kiwifruit peel extracts

AU - Kawase, Masami

AU - Motohashi, Noboru

AU - Satoh, Kazue

AU - Sakagami, Hiroshi

AU - Nakashima, Hideki

AU - Tani, Satoru

AU - Shirataki, Yoshiaki

AU - Kurihara, Teruo

AU - Spengler, G.

AU - Wolfard, Krisztina

AU - Molnár, J.

PY - 2001

Y1 - 2001

N2 - Various bioactive substances in kiwifruit extracts were fractionated by organic solvent extractions, followed by silica gel and ODS chromatographies. Both cytotoxic activity and multi-drug resistance reversal activity were found in the less polar fractions. Cytotoxic activity was not always parallel the radical intensity. Antibacterial activity was distributed into various fractions and all fractions were inactive against Candida albicans and H. pylori. Only 70% methanol extracts showed anti-human immunodeficiency virus activity, and produced a broad ESR signal under alkaline conditions, in a fashion similar to lignin. These fractions also effectively scavenged O2- produced by the xanthine-xanthine oxidase reaction, suggesting a bimodal (pro-oxidant and antioxidant) action. These data suggest a medicinal efficacy of kiwifruit peel extracts.

AB - Various bioactive substances in kiwifruit extracts were fractionated by organic solvent extractions, followed by silica gel and ODS chromatographies. Both cytotoxic activity and multi-drug resistance reversal activity were found in the less polar fractions. Cytotoxic activity was not always parallel the radical intensity. Antibacterial activity was distributed into various fractions and all fractions were inactive against Candida albicans and H. pylori. Only 70% methanol extracts showed anti-human immunodeficiency virus activity, and produced a broad ESR signal under alkaline conditions, in a fashion similar to lignin. These fractions also effectively scavenged O2- produced by the xanthine-xanthine oxidase reaction, suggesting a bimodal (pro-oxidant and antioxidant) action. These data suggest a medicinal efficacy of kiwifruit peel extracts.

KW - Actinidia deliciosa

KW - Actinidiaceae

KW - Anti-HIV activity

KW - Cytotoxic activity

KW - Fractionation

KW - Kiwifruit peel extracts

KW - Radical intensity

UR - http://www.scopus.com/inward/record.url?scp=0034963007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034963007&partnerID=8YFLogxK

U2 - 10.1002/ptr.876

DO - 10.1002/ptr.876

M3 - Article

C2 - 11406859

AN - SCOPUS:0034963007

VL - 15

SP - 337

EP - 343

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 4

ER -