Biological activity of a fruit vegetable, "Anastasia Green", a species of sweet pepper

N. Motohashi, T. Kurihara, H. Wakabayashi, M. Yaji, I. Mucsi, J. Molnár, S. Maruyama, H. Sakagami, H. Nakashima, S. Tani, Y. Shirataki, M. Kawase

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Russian green sweet pepper (Anastasia Green) was successively extracted with hexane, acetone, methanol and 70% methanol and the extracts were further separated into a total of twenty fractions by silica gel or ODS column chromatographies. The biological activities of these extracts and fractions were compared. The extracts and fractions showed higher cytotoxic activity against two human oral tumor cell lines than against normal human gingival fibroblasts, suggesting their tumor-specific action. Several fractions [H3, H4, A4] reversed the multidrug resistant gene (MDR1) against L5178 mouse T-cell lymphoma more effectively than (±) verapamil (positive control). All extracts and fractions showed no anti-human immunodeficiency virus (HIV) nor anti-Helicobacter pylori activity. These data suggest the medicinal importance of an Anastasia Green extract.

Original languageEnglish
Pages (from-to)437-442
Number of pages6
JournalIn Vivo
Volume15
Issue number5
Publication statusPublished - 2001

Fingerprint

Capsicum
Vegetables
Fruits
Bioactivity
Methanol
Tumors
Fruit
Column chromatography
T-cells
T-Cell Lymphoma
Silica Gel
Hexanes
Fibroblasts
Verapamil
Acetone
Tumor Cell Line
Viruses
Helicobacter pylori
Chromatography
Genes

Keywords

  • Anti-H. pylori activity
  • Anti-HIV activity
  • Cytotoxic activity
  • MDR reversal
  • Russian green sweet pepper (Anastasia Green) extracts

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Motohashi, N., Kurihara, T., Wakabayashi, H., Yaji, M., Mucsi, I., Molnár, J., ... Kawase, M. (2001). Biological activity of a fruit vegetable, "Anastasia Green", a species of sweet pepper. In Vivo, 15(5), 437-442.

Biological activity of a fruit vegetable, "Anastasia Green", a species of sweet pepper. / Motohashi, N.; Kurihara, T.; Wakabayashi, H.; Yaji, M.; Mucsi, I.; Molnár, J.; Maruyama, S.; Sakagami, H.; Nakashima, H.; Tani, S.; Shirataki, Y.; Kawase, M.

In: In Vivo, Vol. 15, No. 5, 2001, p. 437-442.

Research output: Contribution to journalArticle

Motohashi, N, Kurihara, T, Wakabayashi, H, Yaji, M, Mucsi, I, Molnár, J, Maruyama, S, Sakagami, H, Nakashima, H, Tani, S, Shirataki, Y & Kawase, M 2001, 'Biological activity of a fruit vegetable, "Anastasia Green", a species of sweet pepper', In Vivo, vol. 15, no. 5, pp. 437-442.
Motohashi N, Kurihara T, Wakabayashi H, Yaji M, Mucsi I, Molnár J et al. Biological activity of a fruit vegetable, "Anastasia Green", a species of sweet pepper. In Vivo. 2001;15(5):437-442.
Motohashi, N. ; Kurihara, T. ; Wakabayashi, H. ; Yaji, M. ; Mucsi, I. ; Molnár, J. ; Maruyama, S. ; Sakagami, H. ; Nakashima, H. ; Tani, S. ; Shirataki, Y. ; Kawase, M. / Biological activity of a fruit vegetable, "Anastasia Green", a species of sweet pepper. In: In Vivo. 2001 ; Vol. 15, No. 5. pp. 437-442.
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