Biological activity of 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones

Anamik Shah, Yogesh Naliapara, Dinesh Sureja, Noboru Motohashi, Teruo Kurihara, Masami Kawase, Kazue Satoh, Hiroshi Sakagami, Joseph Molnár

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Ten 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones (Coumarins) [1-7] and related coumarins [8-10] were compared for their cytotoxic activity and radical intensity. Among these compounds, compound 7 showed highest cytotoxic activity against human promyelocytic leukemic HL-60 cells. Compound 7 produced radicals under alkaline conditions, and showed the lowest π-spin density at S-atom of the molecule, suggesting the delocalization of π-spin density. These data suggest the possible relation between radical intensity and biological activity.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalAnticancer research
Volume18
Issue number1 A
Publication statusPublished - Jan 1 1998

Keywords

  • Coumarins
  • Cytotoxic activity
  • ESR
  • π-spin density

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Shah, A., Naliapara, Y., Sureja, D., Motohashi, N., Kurihara, T., Kawase, M., Satoh, K., Sakagami, H., & Molnár, J. (1998). Biological activity of 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones. Anticancer research, 18(1 A), 61-63.