Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands

Bernadette Sarah Creaven, Eszter Czeglédi, Michael Devereux, Éva Anna Enyedy, Agnieszka Foltyn-Arfa Kia, Dariusz Karcz, Andrew Kellett, Siobhán McClean, Nóra Veronika Nagy, Andy Noble, Antal Rockenbauer, Terézia Szabó-Plánka, Maureen Walsh

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Abstract

The coordination modes of copper(ii) complexes of Schiff base-derived coumarin ligands, which had previously shown good anti-Candida activity, were investigated by pH-potentiometric and UV-Vis spectroscopic methods. These studies confirmed the coordination mode of the ligands to be through the N of the imine and deprotonated phenol of the coumarin-derived ligand in solution. In addition, the more active complexes and their corresponding ligands were investigated in the presence of copper(ii) in liquid and frozen solution by ESR spectroscopic methods. A series of secondary amine derivatives of the Schiff base ligands, were isolated with good solubility characteristics but showed little anti-Candida activity. However, cytotoxicity studies of the secondary amines, together with the copper complexes and their corresponding ligands, against human colon cancer and human breast cancer cells identified the chemotherapeutic potential of these new ligands.

Original languageEnglish
Pages (from-to)10854-10865
Number of pages12
JournalDalton Transactions
Volume39
Issue number45
DOIs
Publication statusPublished - Dec 7 2010

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ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

Creaven, B. S., Czeglédi, E., Devereux, M., Enyedy, É. A., Foltyn-Arfa Kia, A., Karcz, D., Kellett, A., McClean, S., Nagy, N. V., Noble, A., Rockenbauer, A., Szabó-Plánka, T., & Walsh, M. (2010). Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands. Dalton Transactions, 39(45), 10854-10865. https://doi.org/10.1039/c0dt00068j