Biological activities of amyloid precursor protein

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Amyloid precursor protein (APP), a transmembrane glycoprotein, is the source of amyloidogenic β-amyloid peptide (βAP), the major constituent of the peptides deposited in senile plaques. Normally-cleaved forms of APP exert potent neuroprotective action. Accumulating data suggest that an altered expression and/or post-translational processing of APP is responsible for the neuropathological changes observed in Alzheimer's disease and related disorders. This review discusses the metabolism and secretion of APP, the biological activities of the various APP forms, and the physiological, pathophysiological and experimental circumstances that affect the APP metabolism.

Original languageEnglish
Pages (from-to)7-27
Number of pages21
JournalActa Biologica Hungarica
Volume49
Issue number1
Publication statusPublished - 1998

Fingerprint

Amyloid beta-Protein Precursor
amyloid
Bioactivity
bioactive properties
protein
proteins
Metabolism
peptide
metabolism
Peptides
peptides
Amyloid Plaques
neuroprotective effect
transmembrane proteins
Amyloid
secretion
Alzheimer disease
biological activity
protein metabolism
Glycoproteins

Keywords

  • Alzheimer's disease
  • Amyloid
  • Physiology
  • Precursor
  • Protein

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Biological activities of amyloid precursor protein. / Gulya, K.

In: Acta Biologica Hungarica, Vol. 49, No. 1, 1998, p. 7-27.

Research output: Contribution to journalArticle

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