Bioinformatics as a Problem of Knowledge Representation: Applications to Some Aspects of Immunoregulation

Sándor Pongor, A. Falus

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bioinformatics uses a variety of models that fall into three broad categories such as linguistic, three-dimensional and interaction network models. Although the latter allow one to capture interactions among molecules and other cellular components, the underlying representations are predominantly static. The main molecular mechanisms of immunology, such as VJD recombination, cellular and molecular networks and somatic hypermutations, cannot be and are not adequately covered in current molecular databases. Other aspects, such as the maturation of single, monospecific immune response or that of immunological memory, apparently fall outside the scope of current molecular representations. The complexity of immunological regulation, such as the polarized T cell cytokine web, Treg subpopulation, idiotypic networks, etc., calls for a new generation of computational approach, leading to a new age of immunoinformatics ('immunomics').

Original languageEnglish
Title of host publicationImmunogenomics and Human Disease
PublisherJohn Wiley & Sons, Ltd
Pages107-131
Number of pages25
ISBN (Print)9780470015308
DOIs
Publication statusPublished - May 16 2006

Fingerprint

Chemical Databases
Immunologic Memory
Knowledge representation
Bioinformatics
Linguistics
Allergy and Immunology
Computational Biology
Genetic Recombination
Immunology
Cytokines
T-Lymphocytes
T-cells
Data storage equipment
Molecules

Keywords

  • Computer-based prediction methods
  • Expressed sequence tag (EST)
  • Immuno-informatic approach
  • Immunomics concept
  • Interaction network models
  • Language-based descriptions
  • Molecular biology
  • Pathogen-associated molecular pattern (PAMP)
  • Phylogenetic trees

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bioinformatics as a Problem of Knowledge Representation : Applications to Some Aspects of Immunoregulation. / Pongor, Sándor; Falus, A.

Immunogenomics and Human Disease. John Wiley & Sons, Ltd, 2006. p. 107-131.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pongor, Sándor ; Falus, A. / Bioinformatics as a Problem of Knowledge Representation : Applications to Some Aspects of Immunoregulation. Immunogenomics and Human Disease. John Wiley & Sons, Ltd, 2006. pp. 107-131
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