Bioinformatics approaches to the structure and function of intrinsically disordered proteins

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Intrinsically disordered proteins and protein regions (IDPs/IDRs) exist without a well-defined structure. They carry out their function by relying on their highly flexible conformational states and are mostly involved in signal transduction and regulation. By a battery of biophysical techniques, the structural disorder of about 600 proteins has been demonstrated, and functional studies have provided the basis of classifying their functions into various schemes. Indirect evidence suggests that the occurrence of disorder is widespread, and several thousand proteins with significant disorder exist in the human proteome alone. To narrow the wide gap between known and anticipated IDPs, a range of bioinformatics algorithms have been developed, which can reliably predict the disordered state from the amino acid sequence. Attempts have also been made to predict IDP function. However, due to their fast evolution, and reliance on short motifs for function, capturing sequence clues for IDP functions is a much more challenging task. In this chapter we give a brief survey of the IDP field, with particular focus on their functions and bioinformatics approaches developed for predicting their structure and function.

Original languageEnglish
Title of host publicationFrom Protein Structure to Function with Bioinformatics
Subtitle of host publicationSecond Edition
PublisherSpringer Netherlands
Pages167-203
Number of pages37
ISBN (Electronic)9789402410693
ISBN (Print)9789402410679
DOIs
Publication statusPublished - Apr 6 2017

Keywords

  • Conformational ensembles
  • Flexibility
  • Intrinsically unstructured proteins
  • Linear motifs
  • Natively unfolded proteins
  • Prediction methods

ASJC Scopus subject areas

  • Engineering(all)
  • Agricultural and Biological Sciences(all)
  • Environmental Science(all)
  • Economics, Econometrics and Finance(all)
  • Business, Management and Accounting(all)
  • Social Sciences(all)

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  • Cite this

    Dosztányi, Z., & Tompa, P. (2017). Bioinformatics approaches to the structure and function of intrinsically disordered proteins. In From Protein Structure to Function with Bioinformatics: Second Edition (pp. 167-203). Springer Netherlands. https://doi.org/10.1007/978-94-024-1069-3_6