Bioenergetics and the formation of mitochondrial reactive oxygen species

Research output: Contribution to journalArticle

362 Citations (Scopus)

Abstract

The contribution of mitochondria to the manifestation of disease is ascribed largely to the production of reactive oxygen species (ROS), which are obligatory by-products of aerobiosis. Studies using isolated mitochondria have revealed multiple potential sites and circumstances of ROS production but the relevance of these to in situ conditions is limited. In this article, we focus on bioenergetic factors that promote ROS generation at physiologically relevant sites in mitochondria. Emphasis is given to ROS generation by complex I - the first component of the respiratory chain - and to how the NADH:NAD+ ratio regulates ROS formation. Complex I is a physiologically and pathologically relevant ROS-forming site that is important not only in normal mitochondrial energy production but also in the pathogenesis of Parkinson's disease, which is the second most common neurodegenerative disease.

Original languageEnglish
Pages (from-to)639-645
Number of pages7
JournalTrends in Pharmacological Sciences
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 2006

Fingerprint

Energy Metabolism
Reactive Oxygen Species
Mitochondria
NAD
Aerobiosis
Neurodegenerative diseases
Electron Transport
Neurodegenerative Diseases
Byproducts
Parkinson Disease

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Bioenergetics and the formation of mitochondrial reactive oxygen species. / Ádám-Vizi, V.; Chinopoulos, C.

In: Trends in Pharmacological Sciences, Vol. 27, No. 12, 12.2006, p. 639-645.

Research output: Contribution to journalArticle

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