Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

M. Flipphi, Jibin Sun, Xavier Robellet, L. Karaffa, E. Fekete, An Ping Zeng, Christian P. Kubiecek

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Some of the Aspergilli are reputed for their versatile and efficient catabolism of soluble carbon sources and related metabolites as well as raw polymeric materials. Here, we present a detailed investigation of the genomic and evolutionary basis for this versatility, using seven Aspergillus and one Neosartorya genome sequences. We manually annotated about 155 genes per genome covering glycolysis, the pentose phosphate cycle, alternative routes of D-glucose metabolism, catabolism of D-galactose and pentoses, and the TCA cycle, as well as the utilization of acetate and ethanol, propionate metabolism, and gluconeogenesis.The annotation reveals that the Aspergilli have re-enforced several areas of their primary metabolism(notably glycolysis, TCA cycle, ethanol utilization, and pentose and polyol metabolism) by gene duplications,horizontal gene transfer or gene clustering. Results from the phylogenetic analysis of several enzymes encoded by duplicated genes also suggests that some gene products may have acquired new(physiological) functions, that render primary carbon metabolism of the Aspergilli more complex than previously thought.

Original languageEnglish
JournalFungal Genetics and Biology
Volume46 Suppl 1
DOIs
Publication statusPublished - Mar 2009

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Aspergillus nidulans
Biodiversity
Aspergillus
Carbon
Pentoses
Glycolysis
Genes
Neosartorya
Ethanol
Genome
Horizontal Gene Transfer
Gene Duplication
Gluconeogenesis
Propionates
Galactose
Cluster Analysis
Acetates
Phosphates
Glucose
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp. / Flipphi, M.; Sun, Jibin; Robellet, Xavier; Karaffa, L.; Fekete, E.; Zeng, An Ping; Kubiecek, Christian P.

In: Fungal Genetics and Biology, Vol. 46 Suppl 1, 03.2009.

Research output: Contribution to journalArticle

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