Biocompatibility of silver-coated peritoneal dialysis catheter in a porcine model

Leo C.T. Fung, Antoine E. Khoury, Stephan I. Vas, Charles Smith, Dimitrios G. Oreopoulos, Marc W. Mittelman

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Objective: Previous studies have shown that silver formulations coated onto implantable materials retard bacterial colonization and reduce the incidence of catheter related infections. The objective of this study was to assess the histologic effects of sputter-coated silver/silicone implants on host tissue. Design: Sputter silver-coated silicone peritoneal dialysis catheter segments with and without Dacron cuffs were implanted in the subcutaneous fat and muscle in 4 pigs. Noncoated implants served as controls. The specimens were retrieved at 1, 2, 3, 4, 7, 8, 9, 10, 12, and 27 weeks. Experimental Animals: Four 6-week-old male Yorkshire-Landrace pigs (5-6 kg) were used. Main Outcome Measures: Histologic parameters evaluated included the degree of inflammation, the number of giant cells, the extent of silver particulate inclusions, and the thickness of the capsules. All specimens were evaluated by a single blinded pathologist. Microbiologic analyses were also performed. Results: The silver-coated catheters were associated with less inflammation than were the noncoated catheters, both in fat and muscle (p = 0.04). The number of giant cells was also lower around the silver-coated than the noncoated catheters, which were implanted in subcutaneous fat (p < 0.05). Particulate inclusions compatible with silver or silver oxide were observed only in tissue around silver-coated implants (p < 0.0001). The thickness of the capsules and the extent of the inflammatory zones were not significantly different. There was no evidence of infection-related changes. Conclusions: These data suggest that the sputter silver coating does not act as a significant tissue irritant.

Original languageEnglish
Pages (from-to)398-405
Number of pages8
JournalPeritoneal Dialysis International
Issue number4
Publication statusPublished - Oct 19 1996


  • Biocompatible materials
  • Catheter
  • Indwelling
  • Infections
  • Peritoneal dialysis
  • Silver

ASJC Scopus subject areas

  • Nephrology

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    Fung, L. C. T., Khoury, A. E., Vas, S. I., Smith, C., Oreopoulos, D. G., & Mittelman, M. W. (1996). Biocompatibility of silver-coated peritoneal dialysis catheter in a porcine model. Peritoneal Dialysis International, 16(4), 398-405.