Biocompatibility investigation of different pharmaceutical excipients used in liquid dosage forms

D. Nemes, Z. Ujhelyi, P. Arany, A. Peto, P. Feher, J. Váradi, F. Fenyvesi, M. Vecsernyés, I. Bácskay

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3 Citations (Scopus)

Abstract

Aqueous pharmaceutical solutions provide prosperous living conditions for microbiological agents. In order to eliminate these microbes, we use preservatives which can harm human cells as well. Their cytotoxicity is concentration-dependent and the aim of our study was to find how other pharmaceutical excipients modify the cytotoxic attributes of preservatives. We tested the following compounds: methylparaben, benzalkonium chloride, polysorbate 20, Labrasol and hydroxyethyl cellulose. The MTT tests indicated that surfactants increase the cytotoxicity while polymers may decrease it in some cases.

Original languageEnglish
Pages (from-to)16-18
Number of pages3
JournalPharmazie
Volume73
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

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ASJC Scopus subject areas

  • Pharmaceutical Science

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