Biocompatibility investigation of different pharmaceutical excipients used in liquid dosage forms

D. Nemes, Z. Ujhelyi, P. Arany, A. Peto, P. Feher, J. Váradi, F. Fenyvesi, M. Vecsernyés, I. Bácskay

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aqueous pharmaceutical solutions provide prosperous living conditions for microbiological agents. In order to eliminate these microbes, we use preservatives which can harm human cells as well. Their cytotoxicity is concentration-dependent and the aim of our study was to find how other pharmaceutical excipients modify the cytotoxic attributes of preservatives. We tested the following compounds: methylparaben, benzalkonium chloride, polysorbate 20, Labrasol and hydroxyethyl cellulose. The MTT tests indicated that surfactants increase the cytotoxicity while polymers may decrease it in some cases.

Original languageEnglish
Pages (from-to)16-18
Number of pages3
JournalPharmazie
Volume73
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

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Pharmaceutical Solutions
Benzalkonium Compounds
Polysorbates
Excipients
Social Conditions
Dosage Forms
Surface-Active Agents
Cellulose
Polymers
Pharmaceutical Preparations
methylparaben
Labrasol

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Biocompatibility investigation of different pharmaceutical excipients used in liquid dosage forms. / Nemes, D.; Ujhelyi, Z.; Arany, P.; Peto, A.; Feher, P.; Váradi, J.; Fenyvesi, F.; Vecsernyés, M.; Bácskay, I.

In: Pharmazie, Vol. 73, No. 1, 01.01.2018, p. 16-18.

Research output: Contribution to journalArticle

Nemes, D. ; Ujhelyi, Z. ; Arany, P. ; Peto, A. ; Feher, P. ; Váradi, J. ; Fenyvesi, F. ; Vecsernyés, M. ; Bácskay, I. / Biocompatibility investigation of different pharmaceutical excipients used in liquid dosage forms. In: Pharmazie. 2018 ; Vol. 73, No. 1. pp. 16-18.
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