Biochemistry of opioid (morphine) receptors: Binding, structure and molecular modelling

S. Benyhe, Ferenc Zádor, F. Ötvös

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Morphine is the most widely used compound among narcotic analgesics and remains the gold standard when the effects of other analgetic drugs are compared. The most characteristic effect of morphine is the modulation of pain perception resulting in an increase in the threshold of noxious stimuli. Antinociception induced by morphine is mediated via opioid receptors, namely the μ-type opioid receptor. Apart from the μ-opioid receptor, two other classical opioid receptors κ- and δ- and one non-classical opioid receptor, the nociceptin receptor was discovered and cloned so far. At the same time endogenous opioids were also discovered, such as enkephalins, endorphins, and dynorphins. The opioid receptors together with the endogenous opioids form the so called endogenous opioid system, which is highly distributed throughout the body and apart from analgesia it has several other important physiological functions. In this article we will review the historical milestones of opioid research - in detail with morphine. The review will also cover the upmost knowledge in the molecular structure and physiological effects of opioid receptors and endogenous opioids and we will discuss opioid receptor modelling - a rapidly evolving field in opioid receptor research.

Original languageEnglish
Pages (from-to)17-37
Number of pages21
JournalActa Biologica Szegediensis
Volume59
Publication statusPublished - 2015

Fingerprint

Biochemistry
Molecular modeling
morphine
mu Opioid Receptor
narcotics
Opioid Receptors
Molecular Structure
biochemistry
Opioid Analgesics
receptors
Morphine
Endorphins
Dynorphins
Pain Perception
Enkephalins
Narcotics
Research
Analgesia
Molecular structure
endorphins

Keywords

  • Heterogeneity
  • Molecular modelling
  • Molecular structure
  • Morphine
  • Oligomerization
  • Opioid receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Biochemistry of opioid (morphine) receptors : Binding, structure and molecular modelling. / Benyhe, S.; Zádor, Ferenc; Ötvös, F.

In: Acta Biologica Szegediensis, Vol. 59, 2015, p. 17-37.

Research output: Contribution to journalArticle

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