Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases

Antonio C. Bianco, Domenico Salvatore, B. Gereben, Marla J. Berry, P. Reed Larsen

Research output: Contribution to journalArticle

1196 Citations (Scopus)

Abstract

The goal of this review is to place the exciting advances that have occurred in our understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3, respectively) iodothyronine deiodinases into a biochemical and physiological context. We review new data regarding the mechanism of selenoprotein synthesis, the molecular and cellular biological properties of the individual deiodinases, including gene structure, mRNA and protein characteristics, tissue distribution, subcellular localization and topology, enzymatic properties, structure-activity relationships, and regulation of synthesis, inactivation, and degradation. These provide the background for a discussion of their role in thyroid physiology in humans and other vertebrates, including evidence that D2 plays a significant role in human plasma T3 production. We discuss the pathological role of D3 overexpression causing "consumptive hypothyroidism" as well as our current understanding of the pathophysiology of iodothyronine deiodination during illness and amiodarone therapy. Finally, we review the new insights from analysis of mice with targeted disruption of the Dio2 gene and overexpression of D2 in the myocardium.

Original languageEnglish
Pages (from-to)38-89
Number of pages52
JournalEndocrine Reviews
Volume23
Issue number1
DOIs
Publication statusPublished - 2002

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Iodide Peroxidase
Biochemistry
Cell Biology
Molecular Biology
Selenoproteins
Amiodarone
Tissue Distribution
Structure-Activity Relationship
Hypothyroidism
Genes
Vertebrates
Myocardium
Thyroid Gland
Messenger RNA
Proteins
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. / Bianco, Antonio C.; Salvatore, Domenico; Gereben, B.; Berry, Marla J.; Larsen, P. Reed.

In: Endocrine Reviews, Vol. 23, No. 1, 2002, p. 38-89.

Research output: Contribution to journalArticle

Bianco, Antonio C. ; Salvatore, Domenico ; Gereben, B. ; Berry, Marla J. ; Larsen, P. Reed. / Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. In: Endocrine Reviews. 2002 ; Vol. 23, No. 1. pp. 38-89.
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