Biochemical markers in carbon-tetrachloride- and galactosamine-induced acute liver injuries: The effects of dihydroquinoline-type antioxidants

J. Fehér, Zs Bar-Pollak, L. Sreter

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The pharmacological action and possible therapeutic uses of some recently developed synthetic, non-toxic dihydroquinoline-type antioxidants were studied. The effect of the lipid-soluble 6,6-methylene-bis (2,2,4-trimethyl-1,2-dihydroquinoline) (n = 1, 2 or 3) (MTDQ) on carbon-tetrachloride-induced acute liver injuries was investigated, and that of the water-soluble 6,6-methylene-bis (2,2-dimethyl-4-methanesulfonic acid sodium-1,2-dihydroquinoline) (MDS) on galactosamine-induced acute liver injuries in CFLP mice (Lati, Hungary). MTDQ was found suitable for the prevention of acute CCl4-induced liver injuries and MDS for that of acute galactosamine-induced liver injuries. Disappearance or significant diminution of the morphological signs and lesions of lipid degeneration and centrolobular liver necrosis, decrease of serum GOT activities, and also inflammatory changes induced by galactosamine were observed.

Original languageEnglish
Pages (from-to)394-400
Number of pages7
JournalBritish Journal of Experimental Pathology
Volume63
Issue number4
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Biochemical markers in carbon-tetrachloride- and galactosamine-induced acute liver injuries: The effects of dihydroquinoline-type antioxidants'. Together they form a unique fingerprint.

  • Cite this