Biochemical and morphological changes in liver and gallbladder bile of broiler chicken exposed to heavy metals (cadmium, lead, mercury)

A. Blázovics, M. Abaza, P. Sipos, K. Szentmihályi, E. Fehérs, M. Szilágyi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The toxic effects of cadmium, lead and mercury on liver, kidney, lung, bone and testis have been well established. We have hardly any information, however, on the presence of cadmium, lead and mercury in gallbladder bile. Cd, Pb and Hg may precipitate with other elements during gallstone formation and infiltrate the gallstone structure in humans. In order to verify the hypothesis that in gallstone disease trace element toxicosis greatly increases the occurrence of free radical reactions, we performed an experimental study on female broiler chickens. After treatment with Cd, Hg and Pb, dependent on the dose, the hepatocytes store microlipid droplets and in high doses of these metals inflammation and necrosis were observed mainly in the center of the lobules. Good correlation was observed between lipid peroxidation parameters of the liver and bile and total scavenger capacity of the liver in heavy metal poisoning. These data clearly showed that Cd, Pb and Hg exposure promoted free radical reactions and induced oxidative stress in the liver and gallbladder, which contributes to gallstone formation.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalTrace Elements and Electrolytes
Volume19
Issue number1
Publication statusPublished - 2002

Fingerprint

Gallstones
Heavy Metals
Gallbladder
Mercury
Cadmium
Bile
Liver
Chickens
Free radical reactions
Free Radicals
Oxidative stress
Poisons
Trace Elements
Lipid Peroxidation
Testis
Precipitates
Hepatocytes
Bone
Oxidative Stress
Necrosis

Keywords

  • Cd
  • Gallbladder bile
  • Hg
  • Lipid peroxidation
  • Liver
  • Pb

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Biochemical and morphological changes in liver and gallbladder bile of broiler chicken exposed to heavy metals (cadmium, lead, mercury). / Blázovics, A.; Abaza, M.; Sipos, P.; Szentmihályi, K.; Fehérs, E.; Szilágyi, M.

In: Trace Elements and Electrolytes, Vol. 19, No. 1, 2002, p. 42-47.

Research output: Contribution to journalArticle

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AU - Sipos, P.

AU - Szentmihályi, K.

AU - Fehérs, E.

AU - Szilágyi, M.

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AB - The toxic effects of cadmium, lead and mercury on liver, kidney, lung, bone and testis have been well established. We have hardly any information, however, on the presence of cadmium, lead and mercury in gallbladder bile. Cd, Pb and Hg may precipitate with other elements during gallstone formation and infiltrate the gallstone structure in humans. In order to verify the hypothesis that in gallstone disease trace element toxicosis greatly increases the occurrence of free radical reactions, we performed an experimental study on female broiler chickens. After treatment with Cd, Hg and Pb, dependent on the dose, the hepatocytes store microlipid droplets and in high doses of these metals inflammation and necrosis were observed mainly in the center of the lobules. Good correlation was observed between lipid peroxidation parameters of the liver and bile and total scavenger capacity of the liver in heavy metal poisoning. These data clearly showed that Cd, Pb and Hg exposure promoted free radical reactions and induced oxidative stress in the liver and gallbladder, which contributes to gallstone formation.

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