BioArena studies: Unique function of endogenous formaldehyde and ozone in the antibiotic effect - A review

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9 Citations (Scopus)

Abstract

The investigations demonstrated clearly a unique function and role of endogenous formaldehyde (HCHO) and ozone (O 3) in the antibiotic effect of diverse molecules having different chemical structure. Elimination of HCHO and/or O 3 from the layer chromatographic spots resulted in a decrease in the antimicrobial activity. On the basis of detection and measure of endogenous HCHO and O 3 BioArena enables to both direct isolation and biological evaluation of new bioactive compounds.

Original languageEnglish
Pages (from-to)75-84
Number of pages10
JournalMedicinal Chemistry
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 1 2012

Keywords

  • Antibiotic
  • BioArena
  • Cell proliferation
  • Direct bioautography
  • Formaldehyde
  • Hydroxymethyl group
  • OPLC
  • Ozone

ASJC Scopus subject areas

  • Drug Discovery

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