Bioactivity-Guided isolation of antimicrobial and antioxidant metabolites from the mushroom tapinella atrotomentosa

Zoltán Béni, Miklós Dékány, Bernadett Kovács, Boglárka Csupor-L ffler, Zoltán Péter Zomborszki, Erika Kerekes, András Szekeres, Edit Urbán, Judit Hohmann, Attila Ványolós

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6 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1–4. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites were evaluated for their antibacterial activities against several Gram-positive and negative bacteria. In addition, their synergistic effect with cefuroxime against methicillin-resistant Staphylococcus aureus (MRSA) was also evaluated. Compounds 1–3 proved to possess significant antibacterial activity against multiresistant Acinetobacter baumannii and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. The investigation of the antioxidant effect of the isolated compounds in DPPH and ORAC assays revealed that spiromentins C (3) and B (4) have remarkable antioxidant activity.

Original languageEnglish
Article number1082
JournalMolecules
Volume23
Issue number5
DOIs
Publication statusPublished - Jan 1 2018

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Keywords

  • Antibacterial
  • Antioxidant
  • ESBL Escherichia coli
  • Multiresistant Acinetobacter baumannii
  • Tapinella atrotomentosa
  • Terphenyl quinones

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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