Bioactivity-Guided isolation of antimicrobial and antioxidant metabolites from the mushroom tapinella atrotomentosa

Zoltán Béni, Miklós Dékány, Bernadett Kovács, Boglárka Csupor-L ffler, Zoltán Péter Zomborszki, Erika Kerekes, A. Szekeres, E. Urbán, J. Hohmann, Attila Ványolós

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1–4. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites were evaluated for their antibacterial activities against several Gram-positive and negative bacteria. In addition, their synergistic effect with cefuroxime against methicillin-resistant Staphylococcus aureus (MRSA) was also evaluated. Compounds 1–3 proved to possess significant antibacterial activity against multiresistant Acinetobacter baumannii and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. The investigation of the antioxidant effect of the isolated compounds in DPPH and ORAC assays revealed that spiromentins C (3) and B (4) have remarkable antioxidant activity.

Original languageEnglish
Article number1082
JournalMolecules
Volume23
Issue number5
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

metabolites
Agaricales
antioxidants
Metabolites
Bioactivity
isolation
Antioxidants
Acinetobacter baumannii
Cefuroxime
Quinones
Methicillin
Spectroscopic analysis
Bioassay
Gram-Positive Bacteria
Methicillin-Resistant Staphylococcus aureus
Fractionation
Chloroform
Gram-Negative Bacteria
Biological Assay
Escherichia coli

Keywords

  • Antibacterial
  • Antioxidant
  • ESBL Escherichia coli
  • Multiresistant Acinetobacter baumannii
  • Tapinella atrotomentosa
  • Terphenyl quinones

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Béni, Z., Dékány, M., Kovács, B., Csupor-L ffler, B., Zomborszki, Z. P., Kerekes, E., ... Ványolós, A. (2018). Bioactivity-Guided isolation of antimicrobial and antioxidant metabolites from the mushroom tapinella atrotomentosa. Molecules, 23(5), [1082]. https://doi.org/10.3390/molecules23051082

Bioactivity-Guided isolation of antimicrobial and antioxidant metabolites from the mushroom tapinella atrotomentosa. / Béni, Zoltán; Dékány, Miklós; Kovács, Bernadett; Csupor-L ffler, Boglárka; Zomborszki, Zoltán Péter; Kerekes, Erika; Szekeres, A.; Urbán, E.; Hohmann, J.; Ványolós, Attila.

In: Molecules, Vol. 23, No. 5, 1082, 01.01.2018.

Research output: Contribution to journalArticle

Béni Z, Dékány M, Kovács B, Csupor-L ffler B, Zomborszki ZP, Kerekes E et al. Bioactivity-Guided isolation of antimicrobial and antioxidant metabolites from the mushroom tapinella atrotomentosa. Molecules. 2018 Jan 1;23(5). 1082. https://doi.org/10.3390/molecules23051082
Béni, Zoltán ; Dékány, Miklós ; Kovács, Bernadett ; Csupor-L ffler, Boglárka ; Zomborszki, Zoltán Péter ; Kerekes, Erika ; Szekeres, A. ; Urbán, E. ; Hohmann, J. ; Ványolós, Attila. / Bioactivity-Guided isolation of antimicrobial and antioxidant metabolites from the mushroom tapinella atrotomentosa. In: Molecules. 2018 ; Vol. 23, No. 5.
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