Bio-sensing based on plasmon-coupling caused by rotated sub-micrometer gratings in metal-dielectric interfacial layers

M. Csete, Á Sipos, A. Szalai, A. Mathesz, M. A. Deli, Sz Veszelka, A. Schmatulla, A. Koházi-Kis, K. Osvay, O. Marti, Zs Bor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Novel plasmonic sensor chips are prepared by generating sub-micrometer periodic patterns in the interfacial layers of bimetal-polymer films via master-grating based interference method. Poly-carbonate films spin-coated onto vacuum evaporated silver-gold bimetallic layers are irradiated by the two interfering UV beams of a Nd:YAG laser. It is proven by pulsed force mode AFM that periodic adhesion pattern corresponds to the surface relief gratings, consisting of submicrometer droplet arrays and continuous polymer stripes, induced by p- and s-polarized beams, respectively. The characteristic periods are the same, but more complex and larger amplitude adhesion modulation is detectable on the droplet arrays. The polar and azimuthal angle dependence of the resonance characteristic of plasmons is studied by combining the prism- and grating-coupling methods in a modified Kretschmann arrangement, illuminating the structured metal-polymer interface by a frequency doubled Nd:YAG laser through a semi-cylinder. It is proven that the gratingcoupling results in double-peaked plasmon resonance curves on both of the droplet arrays and line gratings, when the grooves are rotated to an appropriate azimuthal angle, and the modulation amplitude of the structure is sufficiently large. Streptavidin seeding is performed to demonstrate that small amount of protein can be detected monitoring the shift of the secondary resonance minima. The available high concentration sensitivity is explained by the promotion of protein adherence in the structure's valleys due to the enhanced adhesion. The line-shaped polymer gratings resulting in narrow resonance peaks are utilized to demonstrate the effect of therapeutic molecules on Amyloid-β peptide, a pathogenic factor in Alzheimer disease.

Original languageEnglish
Title of host publicationAdvanced Environmental, Chemical, and Biological Sensing Technologies V
DOIs
Publication statusPublished - Dec 1 2007
EventAdvanced Environmental, Chemical, and Biological Sensing Technologies V - Boston, MA, United States
Duration: Sep 10 2007Sep 11 2007

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume6755
ISSN (Print)0277-786X

Other

OtherAdvanced Environmental, Chemical, and Biological Sensing Technologies V
CountryUnited States
CityBoston, MA
Period9/10/079/11/07

Keywords

  • Atomic force microscopy
  • Bio-sensing
  • Grating-coupling
  • Surface plasmon resonance spectroscopy
  • Two-beam interference

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Csete, M., Sipos, Á., Szalai, A., Mathesz, A., Deli, M. A., Veszelka, S., Schmatulla, A., Koházi-Kis, A., Osvay, K., Marti, O., & Bor, Z. (2007). Bio-sensing based on plasmon-coupling caused by rotated sub-micrometer gratings in metal-dielectric interfacial layers. In Advanced Environmental, Chemical, and Biological Sensing Technologies V [67550X] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6755). https://doi.org/10.1117/12.752584