Binding overlap and internalization of gonadotropin and thyrotropin in neonatal rat testicle and ovary cell cultures and the Chinese hamster ovary (CHO) cell line.

M. Gruszczynska, O. Török, G. Csaba

Research output: Contribution to journalArticle

Abstract

Colloidal-gold-labeled gonadotropin and colloidal-gold-labeled thyrotropin were bound by Chinese hamster ovary (CHO) and primary neonatal rat ovary and testicle cell cultures in the same sites and in the same quantities. The conditions of internalization and the intracellular fate of the bound gold-labeled hormones were also similar in every respect. Pretreatment with either hormone imprinted the cells also for the related hormone, as judged from the increased binding and internalizing capacity of the pretreated cells for either hormone, and from identical patterns of post-binding receptor aggregation.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalActa Biologica Hungarica
Volume39
Issue number1
Publication statusPublished - 1988

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thyrotropin
Chinese hamsters
Thyrotropin
gonadotropins
Cricetulus
Gonadotropins
Cell culture
hormone
Testis
Rats
Ovary
testes
neonates
cell culture
Cell Culture Techniques
Cells
cell lines
hormones
Hormones
gold

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

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AU - Török, O.

AU - Csaba, G.

PY - 1988

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AB - Colloidal-gold-labeled gonadotropin and colloidal-gold-labeled thyrotropin were bound by Chinese hamster ovary (CHO) and primary neonatal rat ovary and testicle cell cultures in the same sites and in the same quantities. The conditions of internalization and the intracellular fate of the bound gold-labeled hormones were also similar in every respect. Pretreatment with either hormone imprinted the cells also for the related hormone, as judged from the increased binding and internalizing capacity of the pretreated cells for either hormone, and from identical patterns of post-binding receptor aggregation.

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