Binding of non-homologous series of anticancer drugs to cytosine

Research output: Contribution to journalArticle

Abstract

The interaction of 20 anticancer drugs. with cytosine was studied by charge-transfer reversed-phase thin-layer chromatography. The hydrophobicity, the specific hydrophobic surface area and the relative strength of interaction was calculated. Significant linear correlation was found between the hydrophobicity and specific hydrophobic surface area of drugs; this means that, from the chromatographic point of view, they form a homologous series of solutes. Only eight anticancer drugs showed significant interaction with cytosine. The binding of these drugs to cytosine (and possibly to other nucleotides) might be an important interaction which plays a role in the biological activity of drugs.

Original languageEnglish
Pages (from-to)395-401
Number of pages7
JournalBiochemistry and Molecular Biology International
Volume40
Issue number2
Publication statusPublished - 1996

Fingerprint

Cytosine
Pharmaceutical Preparations
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
Thin layer chromatography
Reverse-Phase Chromatography
Thin Layer Chromatography
Bioactivity
Charge transfer
Nucleotides

Keywords

  • Anticancer drugs
  • Charge-transfer chromatography
  • Cytosine

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

Cite this

Binding of non-homologous series of anticancer drugs to cytosine. / Cserháti, T.; Forgács, E.

In: Biochemistry and Molecular Biology International, Vol. 40, No. 2, 1996, p. 395-401.

Research output: Contribution to journalArticle

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