Binding of inositol triphosphate by a liver microsomal fraction

A. Spat, A. Fabiato, R. P. Rubin

Research output: Contribution to journalArticle

85 Citations (Scopus)


Accumulating evidence suggests that the increase in cytosolic Ca2+ induced by receptor agonists is mediated by inositol 1,4,5-triphosphate, a product of phospholipase C-mediated breakdown of phosphatidylinositol 4,5-bisphosphate. The present study employs inositol tris[32P]phosphate to demonstrate a specific receptor binding site in a microsomal fraction of rat liver.

Original languageEnglish
Pages (from-to)929-932
Number of pages4
JournalBiochemical Journal
Issue number3
Publication statusPublished - Jan 1 1986

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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