Binding of inositol triphosphate by a liver microsomal fraction

A. Spät, A. Fabiato, R. P. Rubin

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Accumulating evidence suggests that the increase in cytosolic Ca2+ induced by receptor agonists is mediated by inositol 1,4,5-triphosphate, a product of phospholipase C-mediated breakdown of phosphatidylinositol 4,5-bisphosphate. The present study employs inositol tris[32P]phosphate to demonstrate a specific receptor binding site in a microsomal fraction of rat liver.

Original languageEnglish
Pages (from-to)929-932
Number of pages4
JournalBiochemical Journal
Volume233
Issue number3
Publication statusPublished - 1986

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Inositol 1,4,5-Trisphosphate
Type C Phospholipases
Inositol
Phosphatidylinositols
Liver
Rats
Phosphates
Binding Sites
triphosphoric acid

ASJC Scopus subject areas

  • Biochemistry

Cite this

Binding of inositol triphosphate by a liver microsomal fraction. / Spät, A.; Fabiato, A.; Rubin, R. P.

In: Biochemical Journal, Vol. 233, No. 3, 1986, p. 929-932.

Research output: Contribution to journalArticle

Spät, A, Fabiato, A & Rubin, RP 1986, 'Binding of inositol triphosphate by a liver microsomal fraction', Biochemical Journal, vol. 233, no. 3, pp. 929-932.
Spät, A. ; Fabiato, A. ; Rubin, R. P. / Binding of inositol triphosphate by a liver microsomal fraction. In: Biochemical Journal. 1986 ; Vol. 233, No. 3. pp. 929-932.
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