Binding capacity of rat liver glucocorticoid receptor in different periods after single neonatal benzpyrene treatment (imprinting)

G. Csaba, Ágnes Inczefi-Gonda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Newborn rats of both sexes were treated (imprinted) with 20 μg of benzpyrene. Two hours, 2 days, 1, 2, 3 weeks, 1 month and 2 months after imprinting the liver glucocorticoid receptors were studied for binding of dexamethasone. Two-hour and 2-day values were not appreciable. One week after treatment the receptor's affinity was extremely low both in control and treated treated animals. Two weeks after imprinting a significant difference in density (lower) and affinity (higher) was observed between the male treated and control animals. At 3 weeks and one month the binding capacity of treated and control animals was equal however, at 2 months Bmax of males increased and that of females decreased significantly in the neonatally benzpyrene treated animals. This means that for the development of perinatal imprinting effect a long time is needed, and the effect is manifested after a period of lability.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalActa physiologica Hungarica
Volume88
Issue number2
DOIs
Publication statusPublished - Dec 1 2001

Keywords

  • Benzpyrene
  • Glucocorticoid receptor
  • Hormonal imprinting
  • Liver
  • Newborn

ASJC Scopus subject areas

  • Physiology (medical)

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