Binding ability of thiocarbonyl-containing dipeptides. Potentiometric and spectroscopic studies of copper(II) and nickel(II) coordination

K. Várnagy, I. Sóvágó, Henryk Kozlowski, Teresa Kowalik-Jankowska, Marian Kruszynski, Jolanta Zboinska

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Abstract

Complex formation reactions of thioamide-containing dipeptides (Alat-Ala-OMe and Asp-Phet-NH2) with copper(II) and nickel(II) were studied by the pH-metric and spectroscopic methods. Sulfur donation was established in acidic and neutral media, and it resulted in the enhanced stability of the respective complex species. Already, at pH <3, the S to metal charge transfer band indicated the {NH2S} coordination in cupric complexes. The high stability constants of CuA and CuA2 complexes in comparison to respective complexes with glycine-amide (two and five orders, respectively) also indicate the involvement of sulfur in the metal ion coordination. The thiocarbonyl donor is involved in coordination of nickel(II) ions as well. The stability constants of respective complexes are enhanced, and, according to the spectroscopic data, the NiA2 species is octahedral. It was also found that the coordination of thiocarbonyl donor although it is very effective, cannot prevent an amide nitrogen deprotonation and its coordination to metal ion in basic solutions. According to absorption and c.d. spectra in basic solutions, metal ions are bound to {NHi2N-} donor sets, and resulting complexes MA2H-2 are tetragonal for copper and square-planar for nickel ions.

Original languageEnglish
Pages (from-to)83-93
Number of pages11
JournalJournal of Inorganic Biochemistry
Volume34
Issue number2
DOIs
Publication statusPublished - 1988

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Dipeptides
Nickel
Metal ions
Copper
Ions
Sulfur
Metals
Thioamides
Deprotonation
Amides
Charge transfer
Nitrogen

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Binding ability of thiocarbonyl-containing dipeptides. Potentiometric and spectroscopic studies of copper(II) and nickel(II) coordination. / Várnagy, K.; Sóvágó, I.; Kozlowski, Henryk; Kowalik-Jankowska, Teresa; Kruszynski, Marian; Zboinska, Jolanta.

In: Journal of Inorganic Biochemistry, Vol. 34, No. 2, 1988, p. 83-93.

Research output: Contribution to journalArticle

Várnagy, K. ; Sóvágó, I. ; Kozlowski, Henryk ; Kowalik-Jankowska, Teresa ; Kruszynski, Marian ; Zboinska, Jolanta. / Binding ability of thiocarbonyl-containing dipeptides. Potentiometric and spectroscopic studies of copper(II) and nickel(II) coordination. In: Journal of Inorganic Biochemistry. 1988 ; Vol. 34, No. 2. pp. 83-93.
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