Epeúti szövodmények májtranszplantáció után

Translated title of the contribution: Biliary complications following orthotopic liver transplantation. The Hungarian experience

B. Nemes, Gergely Zádori, Erika Hartmann, Andrea Németh, Imre Fehérvári, Dénes Görög, Zoltán Máthé, Andrea Dávid, Katalin Jakab, E. Sárváry, László Piros, Szabolcs Tóth, János Fazakas, Zsuzsa Gerlei, J. Járay, Attila És Doros

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: The authors summarize the characteristics of biliary complications following liver transplantation in the Hungarian liver transplant program. Aims: were to analyze the frequency and the types of biliary complications as well as their effect on the patient and graft survival. The authors observed the known risk factors in the Hungarian practice, and they also try to find unknown risk factors for biliary complications. They review the terapy of biliary complications. Method: In the retrospective study, patients were divided into two groups, with and without biliary complication after liver transplantation. These two groups were compared with many factors, and with the survivals. The biliary complication group was divided into two parts: those who had an early and those with a late biliary complication. These two new groups were also compared with the controls. The results are summarized in tables and statistical figures. Categorical variables are evaluated by χ2-test, continuous ones are with Levene Test (for homogenicity of means), Student T test and Mann-Whitney U-test. Cumulative survivals are computed with Kaplan-Meier log rank analysis. Results: Biliary complication appeared in 25% of the patients. The most frequent complications were stenosis (18%), biliary leakage (9%), biliary necrosis (6%), and ischaemic type of biliary laesions (3%). The 5-year survival is worse when biliary complications were diagnosed (55%) than without such a complication (66%). In the biliary complication group the retransplantation rate was higher (15%). The most frequent treatments were interventional radiologic methods (69%), surgical methods (17%), and the ERCP. Conclusions: The rate of biliary complications met the international reviews. Risk factors for biliary complications were cholangitis, hepatic artery thrombosis and stenosis, high rate of intraoperative blood transfusions, and acute rejection. Biliary complications frequently associated with the initial poor function of the transplanted graft. Early biliary complications have a negative impact on patient survival, while late complications influence a decreased quality of life. Biliary complications were treated mostly by interventional radiologic procedures.

Original languageHungarian
Pages (from-to)963-973
Number of pages11
JournalOrvosi Hetilap
Volume149
Issue number21
DOIs
Publication statusPublished - May 25 2008

Fingerprint

Liver Transplantation
Survival
Pathologic Constriction
Transplants
Cholangitis
Endoscopic Retrograde Cholangiopancreatography
Hepatic Artery
Graft Survival
Nonparametric Statistics
Blood Transfusion
Thrombosis
Necrosis
Retrospective Studies
Quality of Life
Students
Liver
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nemes, B., Zádori, G., Hartmann, E., Németh, A., Fehérvári, I., Görög, D., ... És Doros, A. (2008). Epeúti szövodmények májtranszplantáció után. Orvosi Hetilap, 149(21), 963-973. https://doi.org/10.1556/OH.2008.28363

Epeúti szövodmények májtranszplantáció után. / Nemes, B.; Zádori, Gergely; Hartmann, Erika; Németh, Andrea; Fehérvári, Imre; Görög, Dénes; Máthé, Zoltán; Dávid, Andrea; Jakab, Katalin; Sárváry, E.; Piros, László; Tóth, Szabolcs; Fazakas, János; Gerlei, Zsuzsa; Járay, J.; És Doros, Attila.

In: Orvosi Hetilap, Vol. 149, No. 21, 25.05.2008, p. 963-973.

Research output: Contribution to journalArticle

Nemes, B, Zádori, G, Hartmann, E, Németh, A, Fehérvári, I, Görög, D, Máthé, Z, Dávid, A, Jakab, K, Sárváry, E, Piros, L, Tóth, S, Fazakas, J, Gerlei, Z, Járay, J & És Doros, A 2008, 'Epeúti szövodmények májtranszplantáció után', Orvosi Hetilap, vol. 149, no. 21, pp. 963-973. https://doi.org/10.1556/OH.2008.28363
Nemes B, Zádori G, Hartmann E, Németh A, Fehérvári I, Görög D et al. Epeúti szövodmények májtranszplantáció után. Orvosi Hetilap. 2008 May 25;149(21):963-973. https://doi.org/10.1556/OH.2008.28363
Nemes, B. ; Zádori, Gergely ; Hartmann, Erika ; Németh, Andrea ; Fehérvári, Imre ; Görög, Dénes ; Máthé, Zoltán ; Dávid, Andrea ; Jakab, Katalin ; Sárváry, E. ; Piros, László ; Tóth, Szabolcs ; Fazakas, János ; Gerlei, Zsuzsa ; Járay, J. ; És Doros, Attila. / Epeúti szövodmények májtranszplantáció után. In: Orvosi Hetilap. 2008 ; Vol. 149, No. 21. pp. 963-973.
@article{afe15417402c4975a408a1ff9ad06ce2,
title = "Epe{\'u}ti sz{\"o}vodm{\'e}nyek m{\'a}jtranszplant{\'a}ci{\'o} ut{\'a}n",
abstract = "Introduction: The authors summarize the characteristics of biliary complications following liver transplantation in the Hungarian liver transplant program. Aims: were to analyze the frequency and the types of biliary complications as well as their effect on the patient and graft survival. The authors observed the known risk factors in the Hungarian practice, and they also try to find unknown risk factors for biliary complications. They review the terapy of biliary complications. Method: In the retrospective study, patients were divided into two groups, with and without biliary complication after liver transplantation. These two groups were compared with many factors, and with the survivals. The biliary complication group was divided into two parts: those who had an early and those with a late biliary complication. These two new groups were also compared with the controls. The results are summarized in tables and statistical figures. Categorical variables are evaluated by χ2-test, continuous ones are with Levene Test (for homogenicity of means), Student T test and Mann-Whitney U-test. Cumulative survivals are computed with Kaplan-Meier log rank analysis. Results: Biliary complication appeared in 25{\%} of the patients. The most frequent complications were stenosis (18{\%}), biliary leakage (9{\%}), biliary necrosis (6{\%}), and ischaemic type of biliary laesions (3{\%}). The 5-year survival is worse when biliary complications were diagnosed (55{\%}) than without such a complication (66{\%}). In the biliary complication group the retransplantation rate was higher (15{\%}). The most frequent treatments were interventional radiologic methods (69{\%}), surgical methods (17{\%}), and the ERCP. Conclusions: The rate of biliary complications met the international reviews. Risk factors for biliary complications were cholangitis, hepatic artery thrombosis and stenosis, high rate of intraoperative blood transfusions, and acute rejection. Biliary complications frequently associated with the initial poor function of the transplanted graft. Early biliary complications have a negative impact on patient survival, while late complications influence a decreased quality of life. Biliary complications were treated mostly by interventional radiologic procedures.",
keywords = "Biliary complications, Hepatic artery thrombosis, Liver transplantation, Percutan transhepatic drainage",
author = "B. Nemes and Gergely Z{\'a}dori and Erika Hartmann and Andrea N{\'e}meth and Imre Feh{\'e}rv{\'a}ri and D{\'e}nes G{\"o}r{\"o}g and Zolt{\'a}n M{\'a}th{\'e} and Andrea D{\'a}vid and Katalin Jakab and E. S{\'a}rv{\'a}ry and L{\'a}szl{\'o} Piros and Szabolcs T{\'o}th and J{\'a}nos Fazakas and Zsuzsa Gerlei and J. J{\'a}ray and {{\'E}s Doros}, Attila",
year = "2008",
month = "5",
day = "25",
doi = "10.1556/OH.2008.28363",
language = "Hungarian",
volume = "149",
pages = "963--973",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "21",

}

TY - JOUR

T1 - Epeúti szövodmények májtranszplantáció után

AU - Nemes, B.

AU - Zádori, Gergely

AU - Hartmann, Erika

AU - Németh, Andrea

AU - Fehérvári, Imre

AU - Görög, Dénes

AU - Máthé, Zoltán

AU - Dávid, Andrea

AU - Jakab, Katalin

AU - Sárváry, E.

AU - Piros, László

AU - Tóth, Szabolcs

AU - Fazakas, János

AU - Gerlei, Zsuzsa

AU - Járay, J.

AU - És Doros, Attila

PY - 2008/5/25

Y1 - 2008/5/25

N2 - Introduction: The authors summarize the characteristics of biliary complications following liver transplantation in the Hungarian liver transplant program. Aims: were to analyze the frequency and the types of biliary complications as well as their effect on the patient and graft survival. The authors observed the known risk factors in the Hungarian practice, and they also try to find unknown risk factors for biliary complications. They review the terapy of biliary complications. Method: In the retrospective study, patients were divided into two groups, with and without biliary complication after liver transplantation. These two groups were compared with many factors, and with the survivals. The biliary complication group was divided into two parts: those who had an early and those with a late biliary complication. These two new groups were also compared with the controls. The results are summarized in tables and statistical figures. Categorical variables are evaluated by χ2-test, continuous ones are with Levene Test (for homogenicity of means), Student T test and Mann-Whitney U-test. Cumulative survivals are computed with Kaplan-Meier log rank analysis. Results: Biliary complication appeared in 25% of the patients. The most frequent complications were stenosis (18%), biliary leakage (9%), biliary necrosis (6%), and ischaemic type of biliary laesions (3%). The 5-year survival is worse when biliary complications were diagnosed (55%) than without such a complication (66%). In the biliary complication group the retransplantation rate was higher (15%). The most frequent treatments were interventional radiologic methods (69%), surgical methods (17%), and the ERCP. Conclusions: The rate of biliary complications met the international reviews. Risk factors for biliary complications were cholangitis, hepatic artery thrombosis and stenosis, high rate of intraoperative blood transfusions, and acute rejection. Biliary complications frequently associated with the initial poor function of the transplanted graft. Early biliary complications have a negative impact on patient survival, while late complications influence a decreased quality of life. Biliary complications were treated mostly by interventional radiologic procedures.

AB - Introduction: The authors summarize the characteristics of biliary complications following liver transplantation in the Hungarian liver transplant program. Aims: were to analyze the frequency and the types of biliary complications as well as their effect on the patient and graft survival. The authors observed the known risk factors in the Hungarian practice, and they also try to find unknown risk factors for biliary complications. They review the terapy of biliary complications. Method: In the retrospective study, patients were divided into two groups, with and without biliary complication after liver transplantation. These two groups were compared with many factors, and with the survivals. The biliary complication group was divided into two parts: those who had an early and those with a late biliary complication. These two new groups were also compared with the controls. The results are summarized in tables and statistical figures. Categorical variables are evaluated by χ2-test, continuous ones are with Levene Test (for homogenicity of means), Student T test and Mann-Whitney U-test. Cumulative survivals are computed with Kaplan-Meier log rank analysis. Results: Biliary complication appeared in 25% of the patients. The most frequent complications were stenosis (18%), biliary leakage (9%), biliary necrosis (6%), and ischaemic type of biliary laesions (3%). The 5-year survival is worse when biliary complications were diagnosed (55%) than without such a complication (66%). In the biliary complication group the retransplantation rate was higher (15%). The most frequent treatments were interventional radiologic methods (69%), surgical methods (17%), and the ERCP. Conclusions: The rate of biliary complications met the international reviews. Risk factors for biliary complications were cholangitis, hepatic artery thrombosis and stenosis, high rate of intraoperative blood transfusions, and acute rejection. Biliary complications frequently associated with the initial poor function of the transplanted graft. Early biliary complications have a negative impact on patient survival, while late complications influence a decreased quality of life. Biliary complications were treated mostly by interventional radiologic procedures.

KW - Biliary complications

KW - Hepatic artery thrombosis

KW - Liver transplantation

KW - Percutan transhepatic drainage

UR - http://www.scopus.com/inward/record.url?scp=45749115460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45749115460&partnerID=8YFLogxK

U2 - 10.1556/OH.2008.28363

DO - 10.1556/OH.2008.28363

M3 - Article

C2 - 18487111

AN - SCOPUS:45749115460

VL - 149

SP - 963

EP - 973

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 21

ER -