Bile flow and biliary excretion rate of some organic anions in phenobarbital-pretreated rats

E. Fischer, F. Varga, Z. Gregus, A. Gogl

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Bile flow and the biliary excretion of indocyanine green, bromcresol green, eosine, bromsulphthalein-glutathione conjugate (BSP-GSH), amaranth and iodoxamic acid were investigated in control and phenobarbital-pretreated rats (75 mg/kg i.p. daily for 5 days). The bile flow was increased by phenobarbital from an average of 50.6 to 77.7 μl/kg/min. Depending on the dose, the biliary excretion rate of bromcresol green was increased by 40-496% and that of eosine by 30-149%. After phenobarbital pretreatment the excretion of BSP-GSH was also enhanced by 34-52%, that of amaranth by 37-53% and that of iodoxamic acid by 40-56%. However, the biliary excretion of indocyanine green remained unchanged. There was no parallelism between the increase in bile flow and biliary excretion of the drugs.

Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalDigestion
Volume17
Issue number3
Publication statusPublished - 1978

Fingerprint

Phenobarbital
Bile
Anions
Bromcresol Green
Indocyanine Green
Eosine Yellowish-(YS)
Glutathione
Hepatobiliary Elimination
Pharmaceutical Preparations
iodoxamic acid

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Bile flow and biliary excretion rate of some organic anions in phenobarbital-pretreated rats. / Fischer, E.; Varga, F.; Gregus, Z.; Gogl, A.

In: Digestion, Vol. 17, No. 3, 1978, p. 211-220.

Research output: Contribution to journalArticle

Fischer, E. ; Varga, F. ; Gregus, Z. ; Gogl, A. / Bile flow and biliary excretion rate of some organic anions in phenobarbital-pretreated rats. In: Digestion. 1978 ; Vol. 17, No. 3. pp. 211-220.
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