Bilateral splanchnicotomy does not affect lipopolysaccharide-induced fever in rats

M. Devrim Dogan, Vladimir A. Kulchitsky, Shreya Patel, Erika Pétervári, Miklós Székely, Andrej A. Romanovsky

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Intraperitoneal capsaicin desensitizes sensory fibers traveling within both the vagus and splanchnic nerves. Because capsaicin desensitization blocks the first phase of lipopolysaccharide (LPS) fever, whereas surgical vagotomy does not, splanchnic mediation of the first phase was proposed. However, all phases of the febrile response of splanchnicotomized rats to intravenous LPS (10 μg/kg) were similar to those of sham-operated controls. Hence, the splanchnic nerve is likely uninvolved in LPS fever.

Original languageEnglish
Pages (from-to)227-229
Number of pages3
JournalBrain research
Volume993
Issue number1-2
DOIs
Publication statusPublished - Dec 12 2003

Keywords

  • Capsaicin
  • Febrile response
  • Splanchnic nerve
  • Thermoregulation
  • Vagus nerve

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Bilateral splanchnicotomy does not affect lipopolysaccharide-induced fever in rats'. Together they form a unique fingerprint.

  • Cite this

    Dogan, M. D., Kulchitsky, V. A., Patel, S., Pétervári, E., Székely, M., & Romanovsky, A. A. (2003). Bilateral splanchnicotomy does not affect lipopolysaccharide-induced fever in rats. Brain research, 993(1-2), 227-229. https://doi.org/10.1016/j.brainres.2003.09.010