Bilateral midbrain transections block the behavioral effects of cholecystokinin on feeding and exploration in rats

J. N. Crawley, J. Z. Kiss, E. Mezey

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The mechanism by which peripherally administered cholecystokinin (CCK) reduces feeding and exploration involves a sensory feedback pathway from the gastrointestinal regions, via the vagus nerve7,22,31 through the nucleus tractus solitarius (NTS)9. Bilateral dorsal midbrain transections rostral to the NTS abolish the ability of CCK to reduce food consumption, decrease exploratory approaches, and increase pauses of behavioral inactivity, as compared to these actions of CCK in normal and sham-lesioned control rats, suggesting that ascending NTS fibers are a necessary component in this feedback system.

Original languageEnglish
Pages (from-to)316-321
Number of pages6
JournalBrain research
Volume322
Issue number2
DOIs
Publication statusPublished - Nov 26 1984

Keywords

  • CCK
  • exploratory behavior
  • feeding behavior
  • midbrain lesions

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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