Bidirectional communication between histamine and cytokines

P. Igaz, I. Novák, E. Lázár, B. Horváth, E. Héninger, A. Falus

Research output: Contribution to journalReview article

64 Citations (Scopus)


Histamine plays fundamental roles in numerous immune reactions. In addition to its well-characterized effects in the acute inflammatory and allergic responses, histamine also influences the expression and actions of several cytokines. The interaction between histamine and the cytokines is bidirectional, since some cytokines were found to modulate the production and release of histamine as well. Because several pharmacological agents that modulate the actions of histamine (e.g. antihistamines) are widely used in the treatment of various human diseases (allergy, peptic ulcer etc.), this complex interaction could have general medical relevance too, but the current situation appears to be rather controversial and further studies are needed to elucidate these sophisticated interactions more precisely.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalInflammation Research
Issue number3
Publication statusPublished - Apr 7 2001


  • Cytokine
  • Histamine
  • Inflammatory
  • T-cell

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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