Bidirectional communication between histamine and cytokines

P. Igaz, I. Novák, E. Lázár, B. Horváth, E. Héninger, A. Falus

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Histamine plays fundamental roles in numerous immune reactions. In addition to its well-characterized effects in the acute inflammatory and allergic responses, histamine also influences the expression and actions of several cytokines. The interaction between histamine and the cytokines is bidirectional, since some cytokines were found to modulate the production and release of histamine as well. Because several pharmacological agents that modulate the actions of histamine (e.g. antihistamines) are widely used in the treatment of various human diseases (allergy, peptic ulcer etc.), this complex interaction could have general medical relevance too, but the current situation appears to be rather controversial and further studies are needed to elucidate these sophisticated interactions more precisely.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalInflammation Research
Volume50
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Histamine
Communication
Cytokines
Antigen-antibody reactions
Histamine Release
Histamine Antagonists
Allergies
Peptic Ulcer
Hypersensitivity
Pharmacology

Keywords

  • Cytokine
  • Histamine
  • Inflammatory
  • T-cell

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)
  • Immunology
  • Cell Biology

Cite this

Bidirectional communication between histamine and cytokines. / Igaz, P.; Novák, I.; Lázár, E.; Horváth, B.; Héninger, E.; Falus, A.

In: Inflammation Research, Vol. 50, No. 3, 2001, p. 123-128.

Research output: Contribution to journalArticle

Igaz, P, Novák, I, Lázár, E, Horváth, B, Héninger, E & Falus, A 2001, 'Bidirectional communication between histamine and cytokines', Inflammation Research, vol. 50, no. 3, pp. 123-128. https://doi.org/10.1007/s000110050735
Igaz, P. ; Novák, I. ; Lázár, E. ; Horváth, B. ; Héninger, E. ; Falus, A. / Bidirectional communication between histamine and cytokines. In: Inflammation Research. 2001 ; Vol. 50, No. 3. pp. 123-128.
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