A genetikán is túl - Az epigenetika eloretörése és orvosi vonatkozásai

Translated title of the contribution: Beyond genetics - The emerging role of epigenetics and its clinical aspects

Veronika S. Urbán, Elizabeta Benevolenskaya, Judit Kiss, Bernadett Sági, Beáta Hegyi, F. Uher

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Analysis of genomic sequences has clearly shown that the genomic differences among species do not explain the diversity of life. The genetic code itself serves as only a part of the dynamic complexity that results in the temporal and spatial changes in cell phenotypes during development. It has been concluded that the phenotype of a cell and of the organism as a whole is more influenced by environmentally-induced changes in gene activity than had been previously thought. The emerging field of epigenetics focuses on molecular marks on chromatin; called the epigenome, which serve as transmitters between the genome and the environment. These changes not only persist through multiple cell division cycles, but may also endure for multiple generations. Irregular alterations of the epigenome; called epimutations, may have a decisive role in the etiology of human pathologies such as malignancies and other complex human diseases. Epigenetics can provide the missing link between genetics, disease and the environment. Therefore, this field may have an increasing impact on future drug design and serve as a basis for new therapeutic/preventative approaches.

Original languageHungarian
Pages (from-to)214-221
Number of pages8
JournalOrvosi Hetilap
Volume153
Issue number6
DOIs
Publication statusPublished - Feb 1 2012

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Epigenomics
Genetic Code
Phenotype
Inborn Genetic Diseases
Drug Design
Chromatin
Sequence Analysis
Cell Cycle
Genome
Pathology
Genes
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Urbán, V. S., Benevolenskaya, E., Kiss, J., Sági, B., Hegyi, B., & Uher, F. (2012). A genetikán is túl - Az epigenetika eloretörése és orvosi vonatkozásai. Orvosi Hetilap, 153(6), 214-221. https://doi.org/10.1556/OH.2012.29301

A genetikán is túl - Az epigenetika eloretörése és orvosi vonatkozásai. / Urbán, Veronika S.; Benevolenskaya, Elizabeta; Kiss, Judit; Sági, Bernadett; Hegyi, Beáta; Uher, F.

In: Orvosi Hetilap, Vol. 153, No. 6, 01.02.2012, p. 214-221.

Research output: Contribution to journalArticle

Urbán, VS, Benevolenskaya, E, Kiss, J, Sági, B, Hegyi, B & Uher, F 2012, 'A genetikán is túl - Az epigenetika eloretörése és orvosi vonatkozásai', Orvosi Hetilap, vol. 153, no. 6, pp. 214-221. https://doi.org/10.1556/OH.2012.29301
Urbán, Veronika S. ; Benevolenskaya, Elizabeta ; Kiss, Judit ; Sági, Bernadett ; Hegyi, Beáta ; Uher, F. / A genetikán is túl - Az epigenetika eloretörése és orvosi vonatkozásai. In: Orvosi Hetilap. 2012 ; Vol. 153, No. 6. pp. 214-221.
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